靶向CXCR4纳米毒素在肿瘤中的研究进展  

Research progress of targeting CXCR4 nanotoxins in tumors

作　　者：侯孟森 阎于珂 李立群 全赢 赵永忠 田勇 杨晓军[2] HOU Mengsen;YAN Yuke;LI Liqun;QUAN Ying;ZHAO Yongzhong;TIAN Yong;YANG Xiaojun(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;Second Department of General Surgery,Gansu Provincial People's Hospital,Lanzhou 73000,China;School of Clinical Medicine,Ningxia Medical University,Yinchuan 750001,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省人民医院普外二科,兰州730000 [3]宁夏医科大学临床医学院,银川750001

出　　处：《生命的化学》2024年第4期694-699,共6页Chemistry of Life

基　　金：甘肃省创新基地和人才项目(20JR10RA433);甘肃省省级科技计划重点研发项目(21YF5WA027);国家卫健委胃肠肿瘤诊治重点实验室2022年度硕博士/博士后基金项目(NHCDP2022001);甘肃省人民医院博士研究生导师培育项目(22GSSYA-3);甘肃省自然科学基金项目(20JR10RA378)。

摘　　要：现有的很多癌症治疗方法常伴有严重的不良反应,因此,迫切需要一种新的治疗方法。近年来,靶向C-X-C趋化因子受体4(C-X-C motif chemokine receptor 4,CXCR4)纳米毒素用于癌症治疗受到广泛关注,其在治疗癌症的过程中通过靶向肿瘤细胞释放毒素而发挥作用,改善了其他临床药物治疗的局限性。然而,这种治疗方法在大多数癌症中尚处于研究阶段。在此,本文描述了多种新型靶向CXCR4纳米毒素在不同肿瘤中的研究现状,介绍了靶向CXCR4纳米毒素的结构组成及作用机制,并简要总结了该治疗方法的优点,为靶向CXCR4纳米毒素应用于临床肿瘤治疗提供理论依据。Many existing cancer treatment methods often come with serious adverse reactions. Therefore,there is an urgent need for a new treatment method. In recent years, targeted C-X-C chemokine receptor 4(CXCR4) nano toxins have received widespread attention for cancer treatment. They play a role in cancer treatment by targeting tumor cells to release toxins, improving the limitations of other clinical drug treatments.However, this treatment method is still in the research stage in most cancers. This paper describes the research status of various novel targeted CXCR4 nanotoxins in different tumors, introduces the structural composition and mechanism of action of targeted CXCR4 nanotoxins, and briefly summarizes the advantages of this treatment method,providing a theoretical basis for the application of targeted CXCR4 nanotoxins in clinical tumor treatment.

关 键 词：CXCR4 靶向CXCR4纳米毒素 细胞凋亡 细胞焦亡 

分 类 号：R73-36[医药卫生—肿瘤]