负载利多卡因的透皮给药系统在口腔颌面部疼痛中的应用效果评价  

The analgesic effects of a lidocaine-loaded transdermal delivery system in orofacial pain

作　　者：王婷 罗涛 支延康[1] 孙宇[1] WANG Ting;LUO Tao;ZHI Yan-kang;SUN Yu(Department of Anesthesiology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine.Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院麻醉科,上海200011

出　　处：《中国口腔颌面外科杂志》2024年第3期222-227,共6页China Journal of Oral and Maxillofacial Surgery

摘　　要：目的:评价负载利多卡因的透皮给药系统在口腔颌面部疼痛模型中的镇痛作用。方法:采用微成型技术,制备负载药物盐酸利多卡因的可溶解微针贴片(Lido/MN),对其插入性能和体外透皮释放能力进行测定。在大鼠口腔颌面部福尔马林炎性疼痛模型和辣椒素致痛模型中观察Lido/MN的镇痛效果,并对其生物安全性进行评价。采用SPSS 21.0软件包对数据进行统计学分析。结果:Lido/MN具有完整平滑的外观形态、优良的机械性能和皮肤刺入性能,能在皮内快速溶解释放利多卡因、快速起效,局麻效果好。结论:Lido/MN的使用,解决了目前利多卡因外用制剂起效慢的问题,具有深入研究的前景和临床意义。PURPOSE:To study the analgesic effect of transdermal drug delivery system loaded lidocaine in orofacial pain model.METHODS:The soluble microneedle patch loaded with lidocaine hydrochloride(Lido/MN)was prepared by microfabrication technology,and its insertion performance and transdermal release ability in vitro were measured.The analgesic effect of Lido/MN was observed in the orofacial formalin-induced pain model and capsaicin induced pain model in rats,and its biological safety was evaluated.SPSS 21.0 software package was used for data analysis.RESULTS:The study demonstrated that Lido/MN exhibited a complete and smooth external morphology,excellent mechanical properties,and skin penetration capability.It could rapidly dissolve and release lidocaine intradermally,exerting a rapid onset of action and providing good local anesthesia.CONCLUSIONS:The use of Lido/MN addresses the issue of slow onset of action in current lidocaine topical formulations,showing promising prospects for further research and clinical significance.

关 键 词：可溶解微针 利多卡因 无创透皮给药 口腔颌面部镇痛 

分 类 号：R730.6[医药卫生—肿瘤]