中药治疗化疗后癌因性疲乏有效性及安全性的Meta分析  

Meta-analysis of Effectiveness and Safety of Traditional Chinese Medicine in the Treatment of Cancer-Related Fatigue after Chemotherapy

作　　者：陈琳俪 张阿润 卜文璐 赵欣然 刘传波[2] 孙韬[2] CHEN Lin-li;ZHANG A-run;BU Wen-lu;ZHAO Xin-ran;LIU Chuan-bo;SUN Tao(The Second Clinical School of Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学第二临床医学院,北京100029 [2]北京中医药大学东方医院,北京100078

出　　处：《云南中医中药杂志》2024年第5期31-39,共9页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：首都卫生发展科研专项项目(2022-2-1023);北京中医药十四五重点专科项目(BJZKBC0003);国家重点研发计划(2018YFC1705100)。

摘　　要：目的系统评价口服中药对癌症患者化疗后癌因性疲乏的疗效与安全性。方法全面检索有关口服中药治疗癌症患者化疗后癌因性疲乏的临床研究,使用(ROB2)风险评估工具对纳入的文献进行质量评价,使用Stata15软件进行Meta分析。结果共纳入30篇文献,合并分析结果显示口服中药联合化疗治疗化疗后癌因性疲乏更有效[RR=1.59,95%CI=(1.40-1.80),P<0.01];Piper评分更低:[SMD=-1.98,CI=(-2.60,-1.36),P<0.01];生活质量更高[SMD=2.04,95%CI=(1.09,2.98),P<0.01]。安全性分析发现,口服中药联合化疗治疗不良反应发生率更低,[RR=0.57,95%CI=(0.48,0.67),P<0.01]。结论结果表明,口服中药联合化疗与单一治疗相比,可以显著的改善癌症患者癌因性疲乏的各种结局指标,说明口服中药治疗癌症患者化疗后癌因性疲乏具有其临床价值。Objective:To systematically evaluate the effectiveness and safety of oral Chinese medicine on cancer-related fatigue after chemotherapy in cancer patients.Methods:Clinical studies related to oral Chinese medicine treatment of cancer patients with cancer-related fatigue after chemotherapy were comprehensively searched.The quality of included literature was evaluated using(ROB2)risk assessment tool,and meta-analysis was performed using Stata15 software.Results:A total of 30 literature were included.The combined analysis showed that oral Chinese medicine combined with chemotherapy was more effective in treating cancer-related fatigue after chemotherapy[RR=1.59,95%CI=(1.40-1.80),P<0.01].Piper score was lower,[SMD=-1.98,CI=(-2.60,-1.36),P<0.01].Quality of life was higher,[SMD=2.04,95%CI=(1.09,2.98),P<0.01].Safety analysis showed that oral Chinese medicine combined with chemotherapy had a lower incidence of adverse reactions[RR=0.57,95%CI=(0.48,0.67),P<0.01].Conclusion:The results show that oral Chinese medicine combined with chemotherapy can significantly improve various outcome indexes of cancer-related fatigue in cancer patients when compared with single therapy,indicating that oral Chinese medicine has its clinical value in treating cancer-related fatigue after chemotherapy.

关 键 词：癌因性疲乏 化疗 口服中药 系统评价 META分析 

分 类 号：R730.5[医药卫生—肿瘤]