血清SAA、CA19-9结合超声内镜对结直肠癌术前分期的诊断价值  

Diagnostic value of serum SAA and CA19-9 combined with endoscopic ultrasonography in preoperative staging of colorectal cancer

作　　者：焦莉莉 周芊池 凌梦芸 魏红玲 徐缨 Jiao Lili;Zhou Qianchi;Ling Mengyun;Wei Hongling;Xu Ying(Health Management Center,Nanjing Mingji Hospital,Nanjing 210019,China)

机构地区：[1]南京明基医院健康管理中心,210019

出　　处：《中华消化病与影像杂志（电子版）》2024年第2期146-150,共5页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的观察血清淀粉样蛋白A(SAA)、糖蛋白抗原(CA)19-9结合超声内镜(EUC)对结直肠癌(CRC)术前分期的诊断价值。方法选取2020年7月至2022年12月南京明基医院收治的并经病理证实的116例CRC患者为研究对象,均进行EUC检查,并检测血清SAA、CA19-9水平,采用ROC曲线分析血清SAA、CA19-9水平联合EUC预测CRC术前分期的诊断价值,并分析血清SAA水平与CA19-9水平的相关性。结果116例CRC患者中,病理分期为T1期22例,T2期28例,T3期46例,T4期20例;N0期66例,N1期30例,N2期20例;M0期100例,M1期16例。EUC诊断为T1期18例,T2期24例,T3期40例,T4期15例;N0期50例,N1期22例,N2期14例;M0期71例,M1期10例;EUC对直肠癌TNM分期的诊断率分别为83.62%、74.14%、69.83%。T分期中T4、T3、T2期的血清SAA、CA19-9水平高于T1期,T4、T3期的血清SAA、CA19-9水平高于T1、T2期,T4期的血清SAA、CA19-9水平高于T1、T2、T3期(P<0.05);N分期中N2、N1期的血清SAA、CA19-9水平高于N0期,N2期的血清SAA、CA19-9水平高于N0、N1期(P<0.05);M分期中M1期的血清SAA、CA19-9水平高于M0期(P<0.05)。ROC曲线分析显示,血清SAA、CA19-9水平联合EUC预测CRC术前分期的敏感度和AUC高于单独检测(P<0.05)。pearson相关分析显示,血清SAA水平与CA19-9的呈正相关(P<0.05)。结论血清SAA、CA19-9结合EUC对CRC术前分期的诊断价值较高,能够为治疗提供参考。Objective To observe the value of serum amyloid A(SAA)and glycoprotein antigen(CA)19-9 combined with endoscopic ultrasonography(EUC)in diagnosing preoperative stages of colorectal cancer(CRC).Methods A total of 116 patients with pathologically confirmed CRC who were admitted to Nanjing Mingji Hospital from July 2020 to December 2022 were selected as the study subjects.All of them received EUC and detection of serum SAA and CA19-9 levels.ROC curve was used to analyze the value of serum SAA and CA19-9 levels combined with EUC in preoperative staging of CRC.The correlation between serum SAA level and CA19-9 level was analyzed.Results For the 116 patients with CRC,the results of pathological staging showed 22 cases in T1 stage,28 cases in T2 stage,46 cases in T3 stage and 20 cases in T4 stage,66 cases in N0 stage,30 cases in N1 stage and 20 cases in N2 stage,100 cases in M0 stage and 16 cases in M1 stage.The diagnostic results of EUC showed 18 cases in T1 stage,24 cases in T2 stage,40 cases in T3 stage and 15 cases in T4 stage,50 cases in N0 stage,22 cases in N1 stage and 14 cases in N2 stage,71 cases in M0 stage and 10 cases in M1 stage.The coincidence rates of EUC for diagnosing TNM stages of CRC were 83.62%,74.14%,and 69.83%,respectively.Serum SAA and CA19-9 levels in T4,T3 and T2 stages were higher than those in T1 stage.Serum SAA and CA19-9 levels in T4 and T3 stages were higher than those in T1 and T2 stages.Serum SAA and CA19-9 levels in T4 stage were higher than those in T1,T2 and T3 stages(P<0.05).Serum SAA and CA19-9 levels in N2 and N1 stages were higher than those in N0 stage.Serum SAA and CA19-9 levels in N2 stage were higher than those in N0 and N1 stages(P<0.05).Serum SAA and CA19-9 levels in M1 stage were higher than those in M0 stage(P<0.05).ROC curve analysis showed that the sensitivity and AUC of serum SAA and CA19-9 levels combined with EUC in diagnosing preoperative stages of CRC were higher than those of diagnosis alone(P<0.05).Pearson correlation analysis showed that serum SAA level was positiv

关 键 词：结直肠癌 淀粉样蛋白A 糖蛋白抗原 超声内镜 术前分期 

分 类 号：R735.34[医药卫生—肿瘤]