IL-6在肿瘤靶向和免疫治疗中的作用  

The roles of IL-6 in tumor targeting and immunotherapy

作　　者：蒲唯高 马晨辉 王云鹏 何普毅 许博 陈昊[1,2] Pu Weigao;Ma Chenhui;Wang Yunpeng;He Puyi;Xu Bo;Chen Hao(Department of Tumor Surgery,Lanzhou University Second Hospital(The Second Clinical Medical College of Lanzhou University),Lanzhou 730030,China;Key Laboratory of Digestive System Tumors of Gansu Province,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院(第二临床医学院)肿瘤外科,兰州730030 [2]兰州大学第二医院消化系统肿瘤重点实验室,兰州730030

出　　处：《中国组织化学与细胞化学杂志》2024年第1期66-75,共10页Chinese Journal of Histochemistry and Cytochemistry

基　　金：国家自然科学基金项目(82160129);甘肃省科技重大专项国际科技合作项目(19ZD2WA001);甘肃省科技重大专项(22ZD6FA054);甘肃省创新驱动助力工程项目(GXH20230817-14)。

摘　　要：炎症作为一把“双刃剑”,与恶性肿瘤的发生、发展及对靶向、免疫治疗的疗效关系密切,可促进或者抑制肿瘤的进展。其中,IL-6作为炎症细胞因子中的重要成员,调控多种肿瘤的病理过程,在临床中被广泛应用并监测,可作为肿瘤细胞增殖、浸润的生物标志物,被认为是衔接炎症与肿瘤最为核心的细胞因子之一。近年来靶向、免疫治疗的出现显示出了良好的疗效,但靶向治疗后部分患者易产生耐药,免疫治疗在实体瘤患者中的平均有效率也较为有限,如何提高靶向和免疫治疗疗效,扩大受益人群是亟待解决的问题。抑制IL-6及其信号转导通路可重启肿瘤-免疫循环,打破免疫抑制的掣肘同时改善免疫微环境,使靶向、免疫治疗更为行之有效。Inflammation acts as a“double-edged sword”,closely related to the occurrence,development,and effectiveness of targeted and immunotherapy treatments in malignant tumors,capable of either promoting or inhibiting tumor progression.Among them,IL-6,as an important member of inflammatory cytokines,regulates the pathological processes of various tumors.It is widely used and monitored in clinical settings and can serve as a biomarker for tumor cell proliferation and infiltration,considered one of the core cytokines linking inflammation and cancer.In recent years,the emergence of targeted and immunotherapy has shown promising effectiveness,but some patients develop resistance to targeted therapies,and the average effectiveness of immunotherapy in solid tumor patients remains limited.How to enhance the effectiveness of targeted and immunotherapy and expand the beneficiary population is an urgent problem to be solved.Inhibiting IL-6 and its signaling pathway can restart the tumor-immune cycle,breaking the constraints of immune suppression while improving the immune microenvironment,making targeted and immunotherapy more effective.

关 键 词：白细胞介素6 炎症 肿瘤 免疫治疗 靶向治疗 

分 类 号：R730.2[医药卫生—肿瘤]