重复经颅磁刺激联合普拉克索治疗中晚期帕金森病合并抑郁的疗效观察  

Clinical efficacy of repetitive transcranial magnetic stimulation and pramipexole in mid and late Parkinson's disease with depression

作　　者：秦锡祥[1] 李伟信 麦永佳 肖远流 莫梓晴 QIN Xi-xiang;LI Wei-xin;MAI Yong-jia;XIAO Yuan-liu;MO Zi-qing(Department of Neurology,Lianjiang People's Hospital,Lianjiang 524400,China)

机构地区：[1]广东省廉江市人民医院神经内科,广东廉江524400

出　　处：《广东医科大学学报》2024年第2期186-189,共4页Journal of Guangdong Medical University

基　　金：湛江市科技计划项目(2022B01141)。

摘　　要：目的观察重复经颅磁刺激(rTMS)联合普拉克索治疗中晚期帕金森病(PD)合并抑郁患者的疗效。方法92例中晚期PD合并抑郁患者随机采用普拉克索(对照组)或rTMS联合普拉克索治疗(观察组)12周。采用汉密尔顿抑郁量表(HAMD)、帕金森病睡眠量表(PDSS)、帕金森病生活质量量表(PDQ-39)评估抑郁程度、睡眠和生活质量,酶联免疫吸附法检测两组患者血清炎症因子水平。结果治疗12周后,观察组HAMD评分、PDQ-39评分、炎症因子(IL-6、IL-1β、IL-8)水平均明显低于对照组,而PDSS评分高于对照组(P<0.01或0.05)。结论rTMS联合普拉克索治疗中晚期PD合并抑郁可减轻抑郁程度,提高睡眠和生活质量。Objective To observe the clinical efficacy of repetitive transcranial magnetic stimulation(rTMS)and pramipexole in mid and late Parkinson's disease(PD)with depression.Methods 92 patients with mid and late PD and depression were randomly treated with pramipexole(control group)or rTMS plus pramipexole(observation group)for 12 weeks.Depression,sleep quality,quality of life,and serum inflammatory factors were detected by Hamilton Depression Scale(HAMD),Parkinson's Disease Sleep Scale(PDSS),Parkinson's Disease Quality of Life Scale(PDQ-39),and enzyme-linked immunosorbent assay,respectively.Results After 12 weeks of treatment,HAMD,PDQ-39 and inflammatory factors(IL-6,IL-1βand IL-8)were lower but PDSS was higher in observation group compared with control group(P<0.01 or 0.05).Conclusion Combined rTMS and pramipexole can improve depression,sleep quality and quality of life in patients with mid and latePD anddepression.

关 键 词：经颅磁刺激 普拉克索 帕金森病 抑郁 

分 类 号：R749.053[医药卫生—神经病学与精神病学]