食欲素对抑郁障碍调节作用的研究进展  

Research progress on the regulation role of orexin on depressive disorder

作　　者：李晓凤 朱敏侠 Li Xiaofeng;Zhu Minxia(Key Laboratory of High Altitude Hypoxia Environment and Life Health,School of Medicine,Xizang Minzu University,Xianyang 712082,China)

机构地区：[1]高原低氧环境与生命健康实验室、西藏民族大学医学院,咸阳712082

出　　处：《中华精神科杂志》2024年第5期313-317,共5页Chinese Journal of Psychiatry

基　　金：国家自然科学基金(82260334);西藏民族大学医学院国家自然科学基金(XZMU-M2022N06)。

摘　　要：抑郁障碍是引起自杀死亡的主要原因。世界卫生组织公布数据显示,2023年全球约有5%的成年人患有抑郁障碍,已成为威胁精神健康事业的首要因素。大量研究表明,神经递质失调是抑郁障碍常见的发病机制。食欲素作为重要神经肽类递质,不仅参与调节睡眠-觉醒和摄食等与抑郁障碍相关的生理反应,而且可直接作用于多个脑区,双向调节抑郁。本文综述了食欲素在不同脑区对抑郁障碍发病的调节作用,以及在急/慢性应激诱导的抑郁障碍中,食欲素分泌水平的变化,以期为抑郁障碍发病机制的基础研究提供参考,为抑郁障碍的临床诊治挖掘新的靶标。Depressive disorder is the main cause of suicide death.According to data released by the World Health Organization,approximately 5%of adults globally suffer from depression in 2023,making it the primary threat to mental health.A large number of studies have shown that neurotransmitter imbalance is a common pathogenesis of depressive disorder.As an important neuropeptide neurotransmitter,orexin not only participates in regulating sleep-wake cycles and feeding behaviors related to depressive disorders,but can also directly act on multiple brain regions to bidirectionally regulate depression.This article reviews the regulatory role of orexin in different brain regions on the pathogenesis of depressive disorders,and the changes in orexin secretion levels in acute/chronic stress-induced depressive disorders.This is intended to provide a reference for the basic research on the pathogenesis of depressive disorders and to explore new targets for the clinical diagnosis and treatment of depressive disorder.

关 键 词：抑郁障碍 食欲素 下丘脑 应激 

分 类 号：R749.4[医药卫生—神经病学与精神病学]