中日韩肝癌流行病学分布对比分析  

Comparison of the epidemiological distribution of liver cancer in China, Japan,and South Korea

作　　者：曹毛毛 杨帆 李倩茹 夏昌发 陈万青 CAO Maomao;YANG Fan;LI Qianru;XIA Changfa;CHEN Wanqing(Office of Cancer Screening,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院癌症早诊早治办公室,北京100021

出　　处：《中华肿瘤防治杂志》2024年第4期205-209,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金(81974492,82273721)。

摘　　要：目的 分析中日韩三国肝癌流行病学情况,从而为降低肝癌疾病负担提供基础信息。方法 数据来源包括全球癌症流行病学数据库(GLOBOCAN) 2020 Cancer Today数据库以及全球疾病负担(Global Burden of Disease)数据库,分别描述三国的肝癌年龄标准化发病率(以下简称发病率)、年龄标准化死亡率(以下简称死亡率)以及肝癌归因比例。同时,通过计算肝癌死亡发病比比较中日韩三国肝癌生存情况。结果 中国肝癌发病例数和死亡例数最高,分别为410 038和391 152例,发病率和死亡率分别为18.2/10万和17.2/10万。中日韩三国中,男性人群的肝癌发病率(依次为27.6/10万、16.1/10万和23.0/10万)高于女性(依次为9.0/10万、5.3/10万和6.5/10万)。同样,中日韩三国男性人群的肝癌死亡率(依次为26.1/10万、7.8/10万和16.5/10万)也高于女性(依次为8.6/10万、2.3/10万和4.3/10万)。对常见癌症的死亡发病比比较发现,肝癌在3个国家中均位列第2位,但不同国家对比可发现中国的肝癌死亡发病比(0.954)最高,其次为韩国(0.755),日本肝癌死亡发病比最低(0.617)。中国和韩国的肝癌发病和死亡50.00%以上归因于慢性HBV感染,但在日本,肝癌的主要危险因素为HCV感染,其发病归因比例为71.39%,死亡归因比例为72.58%。结论 在中日韩三国中,肝癌的疾病负担仍然相当严峻,肝癌危险因素分布存在明显差异。Objective To analyze the epidemiology of liver cancer in China, Japan, and South Korea, in order to provide fundamental information for reducing the disease burden of liver cancer.Methods Data sources include the GLOBOCAN 2020 Cancer Today database and the Global Burden of Disease database. The study described the incidence and mortality rates of liver cancer in the three countries, as well as liver cancer attributable fractions. Additionally, the differences in mortality-to-incidence ratios among the three countries were computed and compared. Results China has the highest number of liver cancer cases and deaths(410 038 cases and 391 152 cases, respectively), with incidence and mortality rates of 18.2 per 100 000 and 17.2 per 100 000 respectively. Across all countries, the incidence liver cancer is higher in males(27.6 per 100 000, 16.1 per 100 000, 23.0 per 100 000, respectively) than females(9.0 per 100 000, 5.3 per 100 000, 6.5 per 100 000, respectively). Likewise, the mortality rate is higher in males(26.1 per 100 000, 7.8 per 100 000, 16.5 per 100 000) than females(8.6 per 100 000, 2.3 per 100 000, 4.3 per 100 000, respectively). Liver cancer has the second mortality-to-incidence ratio among common cancers in the three countries. However, the highest mortality-to-incidence ratio of liver cancer is found in China(0.954), followed by South Korea(0.755), and Japan(0.617). The incidence and mortality of liver cancer in China and South Korea are attributed to chronic HBV infection in over 50.00% of cases. However, in Japan, the primary risk factor for liver cancer is HCV infection, with an attributable fraction of 71.39% for incidence and 72.58% for mortality. Conclusion Liver cancer remains a significant disease burden in China, Japan, and South Korea, with noticeable differences in the distribution of risk factors associated with liver cancer.

关 键 词：肝癌 疾病负担 发病率 死亡率 中国 日本 韩国 

分 类 号：R735.7[医药卫生—肿瘤]