Neuroimmune regulation in the pancreas  

作　　者：Xiaofan Ding Jianhui Chen Wenwen Zeng 

机构地区：[1]Institute for Immunology and School of Basic Medical Sciences,Tsinghua University,and Tsinghua-Peking Center for Life Sciences,Beijing 100084,China [2]Beijing Key Laboratory for Immunological Research on Chronic Diseases,Beijing 100084,China

出　　处：《Fundamental Research》2024年第2期201-205,共5页自然科学基础研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(32225019,3239400331822018,31770936);the National Key R&D Program of China(2023YFC2306300);Beijing Natural Science Foundation(5222010);the Tsinghua University(School of Medicine)-Xiamen Changgeng Hospital Co Ltd Joint Research Center for Anaphylactic Disease;supported by the Center for Life Sciences,the Institute for Immunology,and School of Medicine at Tsinghua University.

摘　　要：The pancreas exerts endocrine and exocrine functions in energy balance.The neural innervation and immune milieu are both crucial in supporting pancreatic homeostasis.The neuronal network connects the pancreas with the central nervous system(CNS)and the enteric nervous system(ENS)and sustains metabolic activities.The nerves in the pancreas are categorized as spinal sensory afferent fibers,vagal sensory afferent nerves,autonomic fibers of both sympathetic and parasympathetic divisions,and fibers from the ENS and intrapancreatic ganglia.They innervate different regions and various cell types,which collectively determine physiological functions.Studies have established that the diverse pathological conditions,including pancreatitis,diabetes,and pancreatic tumor,are attributed to aberrant immune reactions;however,it is largely not clear how the neuronal network may influence the disease conditions.Enlightened by the recent advances illuminating the organ-wide neuronal architecture and the dysfunctions in pancreatic disorders,this review will highlight emerging opportunities to explore the cellular interrelationship,particularly the neuroimmune components in pancreatic health and diseases.

关 键 词：NEUROIMMUNE PANCREAS Pancreatic neuronal innervation Neuroimmune and pancreatic diseases Metabolism 

分 类 号：R576[医药卫生—消化系统]