Skin neuropathy and immunomodulation in diseases  

作　　者：Manze Zhang Tingting Liu Jing Yang 

机构地区：[1]Department of Biology,Stanford University,Stanford,CA 94305,USA [2]Department of Biochemistry,Weill Cornell Medical College,New York,NY 10065,USA [3]IDG/McGovern Institute for Brain Research,Center for Life Sciences,School of Life Sciences,Peking University,Beijing 100871,China [4]Peking University Third Hospital Cancer Center,Beijing 100191,China

出　　处：《Fundamental Research》2024年第2期218-225,共8页自然科学基础研究（英文版）

基　　金：funded by the National Natural Science Foundation of China(31970974,32061143007,32125017,and 32150008);the National Key Research and Development Program of China(2019YFA0802003)。

摘　　要：Skin is a vital barrier tissue of the body.Immune responses in the skin must be precisely controlled,which would otherwise cause severe disease conditions such as psoriasis,atopic dermatitis,or pathogenic infection.Research evidence has increasingly demonstrated the essential roles of neural innervations,i.e.,sensory and sympathetic signals,in modulating skin immunity.Notably,neuropathic changes of such neural structures have been observed in skin disease conditions,implicating their direct involvement in various pathological processes.An in-depth understanding of the mechanism underlying skin neuropathy and its immunomodulatory effects could help reveal novel entry points for therapeutic interventions.Here,we summarize the neuroimmune interactions between neuropathic events and skin immunity,highlighting the current knowledge and future perspectives of this emerging research frontier.

关 键 词：SKIN NEUROPATHY NEUROIMMUNE PSORIASIS Atopic dermatitis Pathogenic infection 

分 类 号：R751[医药卫生—皮肤病学与性病学]