阿尔茨海默病与血脑屏障的相关性研究进展  

Research progress in the relationship between Alzheimer's disease and blood-brain barrier

作　　者：申杰 徐桂华 SHEN Jie;XU Guihua(Department of Neurology,the Third People's Hospital of Shenzhen Longgang District,Shenzhen 518112,China;Department of Neurology,Dongguan Binhaiwan Central Hospital,Dongguan 523900,China;不详)

机构地区：[1]深圳市龙岗区第三人民医院神经内科,广东深圳518112 [2]东莞市滨海湾中心医院神经内科,广东东莞523900 [3]东莞市滨海湾中心医院科教科,广东东莞523900 [4]东莞市滨海湾中心医院东莞市精准医学研究重点实验室,广东东莞523900

出　　处：《实用医学杂志》2024年第11期1602-1606,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81860228);内蒙古自治区自然科学基金项目(编号:2018MS03004);东莞市社会发展科技项目(编号:20211800904462);东莞市滨海湾中心医院高水平科研孵化基金项目(编号:2022001)。

摘　　要：大量研究已证实阿尔茨海默病是一种血脑屏障(BBB)功能障碍相关性疾病,如何通过恢复BBB结构完整性、改善其生理机能,提高AD的转归和预后,必将为该慢病的预防与治疗带来新的视角和机遇。本文就AD的BBB结构功能变化与发病机制、生物标记物及治疗靶点三方面的研究进展综述如下。Numerous studies have confirmed that Alzheimer's disease is a disorder related to dysfunction of blood brain barrier(BBB).How to improve the physiological function of BBB by restoring its structural integrity,and then improve the outcome and prognosis of AD will certainly bring new perspectives and opportunities for the prevention and treatment of this chronic disease.In this article,we review the research progress on AD from three aspects including the structural and functional changes of BBB and its pathogenesis,biomarkers and therapeutic targets.

关 键 词：阿尔茨海默病 血脑屏障 生物标记物 治疗靶点 

分 类 号：R741.02[医药卫生—神经病学与精神病学]