环状RNA与动脉粥样硬化性缺血性脑卒中的研究进展  

Research progress of circrna and atherosclerotic ischemic stroke

作　　者：潘春玲 易雪丽[2,3,4] 苏丽 袁胜山[5] 韦贵将[2,3,4] PAN Chunling;YI Xueli;SU Li;YUAN Shengshan;WEI Guijiang(Youjiang Medical College for Nationalities,Baise 533000,China;不详)

机构地区：[1]右江民族医学院,广西百色533000 [2]右江民族医学院附属医院医学检验中心,广西百色533000 [3]百色市高发病临床分子诊断与研发重点实验室,广西百色533000 [4]广西高校桂西高发病临床分子诊断研究重点实验室,广西百色533000 [5]右江民族医学院附属医院神经内科,广西百色533000

出　　处：《实用医学杂志》2024年第12期1755-1761,共7页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82260418);百色市科学研究与技术开发计划项目(编号:百科20232031)。

摘　　要：脑卒中是危害中老年人身体健康和生命的主要疾病之一,且近年来呈年轻化的趋势发展。它具有发病率高、死亡率高、致残率高等特点,动脉粥样硬化是脑卒中防治的主要干预目标。环状RNA(circRNA)在脑血管系统中高度表达,在缺血性卒中和缺血再灌注损伤的发病机制中起着重要的调节作用。本文综述了circRNA在动脉粥样硬化、缺血性脑卒中、缺血再灌注损伤的病理生理过程中与miRNA分子网络的作用机制,为circRNA在动脉粥样硬化性脑卒中的基因诊断和药物治疗中的应用提供理论支持。Stroke is one of the main diseases endangering the health and life of the middle-aged and elderly,and in recent years it shows a younger trend.It has the characteristics of high incidence,mortality and disability rate.Atherosclerosis is the main intervention target for stroke prevention and treatment.CircRNA is highly expressed in the cerebrovascular system and plays an important regulatory role in the pathogenesis of ischemiareperfusion and ischemic stroke.This paper reviews the mechanism of circRNA and miRNA molecular network in the pathophysiological process of atherosclerosis,ischemic stroke and ischemia-reperfusion injury,so as to provide theoretical support for the application of circRNA in gene diagnosis and drug treatment of atherosclerotic ischemic stroke.

关 键 词：环状RNA 缺血性脑卒中 动脉粥样硬化 病理生理过程 预后 生物标志物 

分 类 号：R743.3[医药卫生—神经病学与精神病学]