增液汤内服及离子导入治疗阴液亏虚证功能性便秘临床研究  

Clinical Study on Oral Administration of Zengye Decoction Combined with Iontophoresis for Functional Constipation with Yin Fluid Depletion Syndrome

作　　者：章新祎 杨丹华[1] 李秀燕[1] ZHANG Xinwei;YANG Danhua;LI Xiuyan(Department of Endocrinology,Zhejiang Provincial Hospital of Chinese Medicine(Qiantang),Hangzhou Zhejiang 310018,China)

机构地区：[1]浙江省中医院钱塘院区内分泌科,浙江杭州310018

出　　处：《新中医》2024年第8期46-50,共5页New Chinese Medicine

摘　　要：目的:观察增液汤内服及离子导入治疗阴液亏虚证功能性便秘(FC)的临床疗效及对胃肠功能的影响。方法:选取87例阴液亏虚证FC为研究对象。根据随机数字表法分为观察组44例与对照组43例。对照组给予乳果糖口服溶液治疗,观察组给予增液汤内服及离子导入治疗。比较2组临床疗效、中医证候评分、胃肠功能血清学指标[胃动素(MTL)、D-乳酸(D-LA)、胃泌素(GAS)、血管活性肠肽(VIP)]改善情况及不良反应发生率。结果:观察组总有效率为97.73%,对照组为86.05%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候中主症、次症评分及总评分均较治疗前减少(P<0.05),且观察组上述各项评分均低于对照组(P<0.05)。治疗后,2组血清MTL水平较治疗前升高(P<0.05),血清D-LA、GAS、VIP水平较治疗前降低(P<0.05);且观察组MTL水平高于对照组(P<0.05),D-LA、GAS、VIP水平低于对照组(P<0.05)。治疗期间,观察组不良反应总发生率为4.55%,对照组为18.60%,2组比较,差异有统计学意义(P<0.05)。结论:增液汤内服及离子导入治疗阴液亏虚证FC,有助于缓解患者临床症状,改善胃肠功能,其疗效及安全性均优于西医常规治疗。Objective:To observe the clinical effects of oral administration of Zengye Decoction and iontophoresis for functional constipation(FC)with yin fluid depletion syndrome and its effects on gastrointestinal function.Methods:A total of 87 cases of patients with FC with yin fluid depletion syndrome were selected as the study objects and divided into the observation group and the control group according to the random number table method,with 44 and 43 cases in each group respectively.The control group was treated with Lactulose Oral Liquid,and the observation group was treated with oral administration of Zengye Decoction and iontophoresis.Clinical effects,traditional Chinese medicine(TCM)syndrome scores,the improvement of gastrointestinal function serological indicators[motilin(MTL),D-lactic acid(D-LA),gastrin(GAS),and vasoactive intestinal peptide(VIP)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 97.73%in the observation group and 86.05%in the control group,the difference being significant(P<0.05).After treatment,the main symptom scores,the secondary symptom scores,and the total scores of TCM syndromes in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of MTL in serum in the two groups were increased when compared with those before treatment(P<0.05),and the levels of D-LA,GAS,and VIP in serum were decreased when compared with those before treatment(P<0.05);the MTL level in the observation group was higher than that in the control group(P<0.05),and the levels of D-LA,GAS,and VIP in serum in the observation group were lower than those in the control group(P<0.05).During treatment,the total incidence of adverse reactions was 4.55%in the observation group and 18.60%in the control group,the difference being significant(P<0.05).Conclusion:Oral administration of Zengye Decoction and iontophoresis for FC

关 键 词：功能性便秘 增液汤 阴液亏虚证 内服 离子导入 胃肠功能 

分 类 号：R574.6[医药卫生—消化系统]