从炎症反应和氧化应激观察参芎正瘫丸治疗缺血性脑卒中临床疗效及其作用机制  

Observation of Clinical Effect and Mechanism of Shenxiong Zhengtan Pills for Ischemic Stroke from Perspectives of Inflammatory Responses and Oxidative Stress

作　　者：郭子华 李丹 张丹 吴茜 姬新颖[4] GUO Zihua;LI Dan;ZHANG Dan;WU Qian;JI Xinying(Department of Neurology,Kaifeng Second Traditional Chinese Medicine Hospital,Kaifeng Henan 475004,China;Department of Pharmacy,Kaifeng Hospital of Chinese Medicine,Kaifeng Henan 475000,China;Department of Neurology,Kaifeng Hospital of Chinese Medicine,Kaifeng Henan 4750o0,China;Henan Provincial International Joint Laboratory for Nuclear Protein Regulation,Kaifeng Henan 475000,China)

机构地区：[1]开封市第二中医院脑病科,河南开封475004 [2]开封市中医院药学部,河南开封475000 [3]开封市中医院脑病科,河南开封475000 [4]河南大学河南省核蛋白基因调控国际联合实验室,河南开封475000

出　　处：《新中医》2024年第8期63-69,共7页New Chinese Medicine

基　　金：河南省科技攻关项目(232102310453)。

摘　　要：目的:从炎症反应和氧化应激探讨参芎正瘫丸治疗缺血性脑卒中患者的临床疗效及其作用机制。方法:选取83例急性期缺血性脑卒中(瘀血阻络型)患者作为研究对象,随机分为2组,对照组41例采取西医常规治疗,治疗组42例采取西医常规治疗联合参芎正瘫丸治疗,持续治疗2周,比较2组临床疗效、中医证候疗效以及凝血功能、氧化应激和炎性因子水平,记录不良反应。结果:研究过程中治疗组脱落1例,2组最终纳入统计各41例。治疗后,治疗组临床疗效显效率高于对照组,差异有统计学意义(P<0.05),2组临床疗效总有效率比较,差异无统计学意义(P>0.05);治疗组中医证候疗效总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,2组抑制核因子κB(NF-κB)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均较治疗前降低,且治疗组低于对照组,差异均有统计学意义(P<0.05);2组超氧化物歧化酶(SOD)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)水平均较治疗前升高,活性氧(ROS)、纤维蛋白原(FIB)水平均较治疗前降低,且治疗组SOD、PT、APTT水平均高于对照组,治疗组ROS及FIB水平均低于对照组,差异均有统计学意义(P<0.05);对照组总不良反应发生率为12.20%,与治疗组总发生率9.76%比较,差异无统计学意义(P>0.05)。结论:参芎正瘫丸能改善血液高凝状态,防止脑缺血后的神经功能恶化,临床疗效确切,且不增加不良反应发生风险。参芎正瘫丸发挥疗效的作用机制可能与抑制炎症反应、改善氧化应激有关。Objective:To discuss the clinical effect and mechanism of Shenxiong Zhengtan Pills on ischemic stroke from the perspectives of inflammatory responses and oxidative stress.Methods:A total of 83 cases of patients with acute ischemic stroke(blood stasis obstruction type)were selected as the study subjects and randomly divided into two groups.The control group(41 cases)received routine western medicine treatment,and the treatment group(42 cases)received routine western medicine treatment combined with Shenxiong Zhengtan Pills.Both groups were treated for 2 weeks.The clinical effects,traditional Chinese medicine(TCM)syndrome effects,coagulation function,oxidative stress,and inflammatory factor levels were compared between the two groups,and adverse reactions were recorded.Results:During the study,one case was dropped out from the treatment group,and 41 cases were ultimately included in the two groups respectively.After treatment,the clinical effect in the treatment group was significantly higher than that in the control group,the difference being significant(P<0.05).There was no significant difference being found in the comparison of total clincial effective rates between the two groups(P>0.05).The total effective rate of TCM syndromes in the treatment group was higher than that in the control group,the difference being significant(P<0.05).After treatment,the levels of nuclear factorκB(NF-κB),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were decreased when compared with those before treatment,and the levels in the treatment group were lower than those in the control group,differences being significant(P<0.05).The levels of superoxide dismutase(SOD),prothrombin time(PT),and activated partial thromboplastin time(APTT)in the two groups were increased when compared with those before treatment,and the levels of reactive oxygen species(ROS)and fibrinogen(FIB)were decreased when compared with those before treatment;the levels of SOD,PT,and APTT in the treatment group were higher than those in the control group,an

关 键 词：缺血性脑卒中 参芎正瘫丸 氧化应激 炎症反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]