参麦注射液辅助西药治疗中风恢复期临床研究  

Clinical Study on Shenmai Injection Assisting Western Medicine for Ischemic Stroke with Deficiency of Both Qi and Yin Syndrome During Convalescence Phase

作　　者：陈徐彬[1] 严平[1] 毛平安[1] CHEN Xubin;YAN Ping;MAO Ping'an(Department of Rehabilitation,Lishui People's Hospital,Lishui Zhejiang 323000,China)

机构地区：[1]丽水市人民医院康复科,浙江丽水323000

出　　处：《新中医》2024年第8期75-79,共5页New Chinese Medicine

摘　　要：目的:观察参麦注射液辅助西药治疗中风恢复期的临床疗效。方法:按随机数字表法将90例中风恢复期患者分为治疗组与对照组各45例。对照组给予阿司匹林肠溶片、胞二磷胆碱注射液、甲钴胺片等西药对症治疗,治疗组在对照组基础上给予参麦注射液治疗。治疗4周后,比较2组临床疗效、中医证候评分、美国国立卫生院神经功能缺损评分(NIHSS)、肢体运动功能Fugel-Meyer评定量表(FMA)及血清炎症因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤细胞因子-α(TNF-α)]水平。结果:治疗后,治疗组总有效率为95.56%,对照组为82.22%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候评分、NIHSS评分均较治疗前降低(P<0.05),且治疗组2项评分均低于对照组(P<0.05)。治疗后,2组上、下肢的FMA评分均较治疗前升高(P<0.05),且治疗组上、下肢的FMA评分均高于对照组(P<0.05)。治疗后,2组血清IL-1β、IL-6、TNF-ɑ水平均较治疗前降低(P<0.05),且治疗组上述各项指标均低于对照组(P<0.05)。结论:参麦注射液辅助西药治疗中风恢复期患者疗效显著,可有效减轻机体炎症反应,缓解临床症状,改善神经功能及肢体运动功能。Objective:To observe the clinical effect of Shenmai Injection assisting western medicine for ischemic stroke with deficiency of both qi and yin syndrome during the convalescence phase.Methods:A total of 90 cases of patients with ischemic stroke with deficiency of both qi and yin syndrome during the convalescence phase were divided into the treatment group and the control group according to the random number table method,with 45 cases in each group.The control group was given symptomatic treatment with western medicine like Aspirin Enteric-Coated Tablets,Citicoline Injection,Mecobalamine Tablets,etc.,and the treatment group was additionally treated with Shenmai injection based on the treatment of the control group.After 4 weeks of treatment,clinical effects,traditional Chinese medicine syndrome(TCM)scores,National Institutes of Health Neurological Impairment Score(NIHSS),Fugel-Meyer Assessment(FMA)of limb motor function and levels of serum inflammatory factors[interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)]were compared between the two groups.Results:After treatment,the total effective rate was 95.56%in the treatment group and 82.22%in the control group,the difference being significant(P<0.05).After treatment,TCM syndrome scores and NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above two scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the FMA scores of upper and lower limbs in the two groups were increased when compared with those before treatment(P<0.05),and the FMA scores of upper and lower limbs in the treatment group were higher than those in the control group(P<0.05).After treatment,the levels of IL-1β,IL-6 and TNF-αin serum in the two groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the treatment group were lower than those in the control group(P<0.05).Conclusion:Shenmai Injection assisting western medicine for patients w

关 键 词：中风 恢复期 参麦注射液 神经功能 炎症因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]