隔姜灸脐法联合胃复春胶囊治疗脾胃虚弱型慢性萎缩性胃炎临床研究  

Clinical Study on Umbilical Moxibustion on Ginger Combined with Weifuchun Cap⁃sules for Chronic Atrophic Gastritis of Spleen-Stomach Weakness Type

作　　者：陈君 童晓群 CHEN Jun;TONG Xiaoqun(Hangzhou Linan Traditional Chinese Medicine Hospital,Hangzhou Zhejiang 311300,China)

机构地区：[1]杭州市临安区中医院,浙江杭州311300

出　　处：《新中医》2024年第8期121-126,共6页New Chinese Medicine

摘　　要：目的:观察隔姜灸脐法联合胃复春胶囊治疗脾胃虚弱型慢性萎缩性胃炎(CAG)的临床疗效。方法:选取138例脾胃虚弱型CAG患者,采用随机数字表法分为对照A组、对照B组、试验组,每组46例。3组均剔除1例,最终纳入研究45例。对照A组予以隔姜灸脐法治疗,对照B组予以胃复春胶囊治疗,试验组予以隔姜灸脐法联合胃复春胶囊治疗。3组均治疗4周。比较3组中医证候疗效,治疗前后胃黏膜病理组织学评分、胃肠激素水平,记录不良反应发生率。结果:治疗后,3组总有效率整体比较,差异有统计学意义(P<0.05)。试验组总有效率91.11%,高于对照A组68.89%、对照B组77.78%(P<0.05)。3组慢性炎症、上皮化生、腺体萎缩、异型增生评分均较治疗前降低(P<0.05);试验组慢性炎症、上皮化生、腺体萎缩、异型增生评分均低于对照A组、对照B组(P<0.05);对照A组与对照B组慢性炎症、上皮化生、腺体萎缩、异型增生评分比较,差异均无统计学意义(P>0.05)。3组血清胃泌素(GAS)、胃蛋白酶原Ⅱ(PGⅡ)、胃动素(MTL)水平均较治疗前升高(P<0.05);试验组血清GAS、PGⅡ、MTL水平均高于对照A组、对照B组(P<0.05);对照A组与对照B组血清GAS、PGⅡ、MTL水平比较,差异均无统计学意义(P>0.05)。不良反应发生率试验组8.89%,对照A组6.67%,对照B组2.22%,3组整体比较,差异无统计学意义(P>0.05)。结论:隔姜灸脐法联合胃复春胶囊治疗脾胃虚弱型CAG可获得显著疗效,能明显改善患者的胃黏膜病理状况及胃肠激素水平,且安全性良好。Objective:To observe the clinical effect of umbilical moxibustion on ginger combined with Weifuchun Capsules for chronic atrophic gastritis(CAG)of spleen-stomach weakness type.Methods:A total of 138 cases of CAG patients of spleen-stomach weakness type were selected and divided into the control group A,the control group B,and the trial group,with 46 cases in each group.One case was excluded from each group,and finally 45 cases were included in each group.The control group A was treated with umbilical moxibustion on ginger,the control group B was treated with Weifuchun Capsules,and the trial group was treated with umbilical moxibustion on ginger combined with Weifuchun Capsules.The three groups were treated for 4 weeks.Traditional Chinese Medicine syndrome effects,as well as gastric mucosal histopathological scores and gastrointestinal hormone levels were compared before and after treatment among the three groups.Adverse reactions incidence rate were recorded.Results:After treatment,there was significant difference in the comparison of the total effective rates among the three groups(P<0.05).The total effective rate was 91.11%in the trial group,higher than that of 68.89%in the control group A and 77.78%in the control group B(P<0.05).The scores of chronic inflammation,epithelial metaplasia,glandular atrophy,and atypical hyperplasia in the three groups were decreased when compared with those before treatment(P<0.05),and the scores of chronic inflammation,epithelial metaplasia,glandular atrophy,and atypical hyperplasia in the trial group were lower than those in the control group A and the control group B(P<0.05);there was no significance difference in the scores of chronic inflammation,epithelial metaplasia,glandular atrophy,and atypical hyperplasia between the control group A and the control group B(P>0.05).The levels of gastrin(GAS),pepsinogenⅡ(PGⅡ),and motilin(MTL)in serum in the three groups were increased when compared with those before treatment(P<0.05);the levels of GAS,PGⅡ,and MTL in serum in the trial

关 键 词：慢性萎缩性胃炎 脾胃虚弱型 隔姜灸脐法 胃复春胶囊 胃黏膜病理组织学评分 胃肠激素 

分 类 号：R573.3+2[医药卫生—消化系统]