微量泵泵入奥曲肽治疗急性胰腺炎的疗效评价  

Evaluation of The Therapeutic Effect of Micropump Infusion of Octreotide in the Treatment of Acute Pancreatitis

作　　者：裔文静 周紫微 王梦婷 YI Wenjing;ZHOU Ziwei;WANG Mengting(Department of Pharmacy,Jurong People′s Hospital,Zhenjiang,Jiangsu Province,212400 China)

机构地区：[1]句容市人民医院药剂科,江苏镇江212400

出　　处：《系统医学》2024年第8期43-46,共4页Systems Medicine

摘　　要：目的探究分析微量泵泵入奥曲肽治疗急性胰腺炎的疗效。方法选取2020年5月—2023年5月句容市人民医院接受奥曲肽治疗的76例急性胰腺炎患者为研究对象,采用随机数表法分组,每组38例。对照组给予静脉滴注奥曲肽治疗,研究组给予微量泵泵入奥曲肽治疗,分析两组疗效、临床指标(腹痛缓解、恶心呕吐缓解、血淀粉酶恢复、住院时间)、炎症因子(白细胞介素-2、C反应蛋白、肿瘤坏死因子-α)、不良反应等。结果研究组治疗总有效率(97.37%)高于对照组(84.21%),差异有统计学意义(χ^(2)=4.434,P=0.047)。研究组腹痛缓解、恶心呕吐缓解、血淀粉酶恢复、住院时间均优于对照组,差异有统计学意义(P均<0.05)。研究组治疗后白细胞介素-2、C反应蛋白、肿瘤坏死因子-α均低于对照组,差异有统计学意义(P均<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(χ^(2)=5.029,P=0.025)。结论急性胰腺炎实施微量泵泵入治疗疗效显著,安全性高,降低炎症情况。Objective To explore the therapeutic effect of octreotide injected by micropump in the treatment of acute pancreatitis.Methods A total of 76 patients with acute pancreatitis treated with octreotide in Jurong People′s Hospital from May 2020 to May 2023 were selected as the research objects,and they were divided into two groups by random number table method,with 38 cases in each group.The control group was treated with intravenous infusion of octreotide,and the study group was treated with micro-pump infusion of octreotide.The efficacy,clinical indicators(abdominal pain relief,nausea and vomiting relief,blood amylase recovery,hospitalization time),inflammatory factors(interleukin-2,C-reactive protein,tumor necrosis factorα)and adverse reactions of the two groups were analyzed.Results The total effective rate of treatment in the study group(97.37%)was higher than that in the control group(84.21%),and the difference was statistically significant(χ^(2)=4.434,P=0.047).The abdominal pain relief,nausea and vomiting relief,blood amylase recovery and hospitalization time in the study group were better than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of interleukin-2,C-reactive protein and tumor necrosis factor-αin the study group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(χ^(2)=5.029,P=0.025).Conclusion The treatment of acute pancreatitis with micropump is effective,safe and can reduce inflammation.

关 键 词：微量泵 奥曲肽 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]