结直肠癌类器官药物敏感性检测指导肿瘤患者精准治疗的研究进展  

Research Progress of Organoid Drug Sensitivity Detection to Guide Precision Treatment of Cancer Patients in Colorectal Cancer

作　　者：王梦杰 王璐[2,3] 樊志敏 WANG Mengjie;WANG Lu;FAN Zhimin(Graduate School of Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu Province,210022 China;Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine,Nanjing,Jiangsu Province,210022 China;Jiangsu Traditional Chinese Medicine Anorectal Diseases Clinical Medi-cal Innovation Center,Nanjing,Jiangsu Province,210022 China)

机构地区：[1]南京中医药大学研究生院,江苏南京210022 [2]南京中医药大学附属南京中医院,江苏南京210022 [3]江苏省中医肛肠疾病临床医学创新中心,江苏南京210022

出　　处：《系统医学》2024年第8期187-191,共5页Systems Medicine

基　　金：江苏省重点研发计划(社会发展)项目(BE2021611)。

摘　　要：结直肠癌作为全球的主要恶性肿瘤之一,其在全世界癌症发病率和病死率中,分别排名第3和第2位。随着精准医疗理念的提出,如何为患者提供更加针对性的治疗方案成为肿瘤治疗的重点问题。尽管结直肠癌的药物治疗在化疗、靶向治疗、免疫治疗等方面取得了进展,但如何更准确地预测药物的疗效仍然是一个挑战。本文概述了结直肠癌的流行病学背景和精准医疗的重要性。对结直肠癌的各类药物治疗方法进行了综述。中心内容则围绕结直肠癌类器官模型在药物敏感性检测中的研究进展,探讨了类器官模型的独特优势及其在直肠癌和结肠癌中的应用。文章还探讨了当前类器官药敏实验在临床应用中存在的主要问题和挑战。旨在推动结直肠癌精准治疗的发展,为患者提供更为个体化的治疗建议,从而提高治疗效果和患者的生活质量。As one of the major malignant tumors in the world,colorectal cancer ranks third and second in the incidence and mortality of cancer worldwide.With the proposed concept of precision medicine,how to provide patients with more targeted treatment programs has become the focus of cancer treatment.Although pharmacological treatment of colorectal cancer has made progress in chemotherapy,targeted therapy,immunotherapy,etc.,how to predict the efficacy of drugs more accurately remains a challenge.This article summarized the epidemiological background of colorectal cancer and the importance of precision medicine.Various drug treatment methods of colorectal cancer were reviewed.The central content focused on the research progress of organoid model in drug sensitivity detection of colorectal cancer,and discussed the unique advantages of organoid model and its application in colorectal cancer and colon cancer.The main problems and challenges in the clinical application of organoid drug sensitivity tests were also discussed.This paper aimed to promote the development of precision therapy for colorectal cancer and provide more individualized treatment recommendations for patients,so as to improve the treatment effect and the quality of life of patients.

关 键 词：结直肠癌 类器官药物敏感性检测 精准治疗 

分 类 号：R574[医药卫生—消化系统]