左旋多巴联合普拉克索治疗帕金森病的临床效果分析  

Clinical Effect Analysis of Levodopa Combined with Pramipexole in the Treatment of Parkinson's Disease

作　　者：王正印[1] 李洪伟 应国民 WANG Zhengyin;LI Hongwei;YING Guomin(Department of Neurology,Shanxian Central Hospital,Heze,Shandong Province,274300 China)

机构地区：[1]单县中心医院神经内科,山东菏泽274300

出　　处：《中外医疗》2024年第11期102-105,共4页China & Foreign Medical Treatment

摘　　要：目的探讨左旋多巴联合普拉克索治疗帕金森病的效果。方法前瞻性单纯随机选取2022年5月—2023年10月单县中心医院收治的100例帕金森病患者为研究对象,随机数表法分为对照组(左旋多巴治疗)与研究组(左旋多巴+普拉克索治疗),各50例。对比两组治疗总有效率、临床症状评分、血清指标、负性情绪评分。结果研究组治疗总有效率为96.00%,高于对照组的80.00%,差异有统计学意义(χ^(2)=6.061,P<0.05)。研究组简易精神状态量表评分高于对照组,帕金森病综合评分量表、帕金森病非运动症状问卷评分低于对照组,差异有统计学意义(P均<0.05)。研究组血清指标优于对照组,汉密尔顿焦虑量表评分(7.82±0.75)分、汉密尔顿抑郁量表评分(7.03±0.87)分低于对照组,差异有统计学意义(P均<0.05)。结论左旋多巴与普拉克索联合使用治疗帕金森病可改善血清指标,缓解负面情绪,使患者临床症状好转,疗效显著。Objective To investigate the effect of levodopa combined with pramipexole in the treatment of Parkinson's disease.Methods 100 patients with Parkinson's disease admitted to Shanxian Central Hospital from May 2022 to October 2023 were prospective and randomly as the study objects,and they were divided into the control group(levodopa treatment)and the study group(levodopa+pramipexole treatment),with 50 cases in each group by random number table method.Treatment efficiency,clinical symptom scores,serum indicators,and negative mood scores were compared between the two groups.Results The total treatment effectiveness rate in the study group was 96.00%,higher than 80.00%in the control group,and the difference was statistically significant(χ^(2)=6.061,P<0.05).Mini Mental State Examination score in the study group was higher than that in the control group,and Unified Parkinson's Disease Rating Scale and Non Motor Symptoms Questionnairet scores were lower in the study group than thsoe in the control group,and the differences were statistically significant(all P<0.05).serum indicators in the study group were higher than those in the control group,and Hamilton Anxiety Scale score(7.82±0.75)points and Hamilton Depression Scale score(7.03±0.87)points were lower in the study group compared to the control group,and the differences were statistically significant(all P<0.05).Conclusion The combined use of levodopa and pramipexole in the treatment of Parkinson's disease can improve the serum indexes,alleviate the negative emotions,improve patient's clinical symptoms,and the efficacy is remarkable.

关 键 词：帕金森病 左旋多巴 普拉克索 血清指标 

分 类 号：R742.5[医药卫生—神经病学与精神病学]