双层片剂的研究进展  

Research Progress on Double-layer Tablets

作　　者：王楠 时晓燕 潘增玉 贾俊伟 冯中 无 WANG Nan;SHI Xiaoyan;PAN Zengyu;JIA Junwei;FENG Zhong;无(School of Pharmaceutical Sciences,Shandong University of Traditional Chinese Medicine,Jinan 250355;International Pharmaceutical Engineering Lab.in Shandong Province,Lunan Pharmaceutical Group Co.,Ltd.,Linyi 273400;Shandong Engineering Research Center for New Drug Pharmaceuticals R&D,Lunan Better Pharmaceutical Co.,Ltd.,Linyi 276006)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]鲁南制药集团股份有限公司,山东省药物国际化工程实验室,山东临沂273400 [3]鲁南贝特制药有限公司,药物新制剂研发山东省工程研究中心,山东临沂276006

出　　处：《中国医药工业杂志》2024年第4期494-500,共7页Chinese Journal of Pharmaceuticals

基　　金：泰山产业领军人才项目(No.TSCX202306086);山东省重大科技创新工程项目(2020CXGC010506)。

摘　　要：双层片剂是一种广受关注的新型制剂,具有双层结构,可通过联合用药或调整释药速率来增强药效、减轻药物不良反应、提高患者依从性。该综述总结了近年来双层片剂的研究进展,汇总了双层片剂的特点、制备方法和分类情况,并结合案例介绍了双层片剂的临床应用情况,以期为双层片剂的研究与开发提供参考。Double-layer tablets are a novel dosage form which attract wide attention.With bilayer structures,double-layer tablets can enhance drug efficacy,reduce adverse drug reactions and improve patient compliance by combination medication or adjusting the release rate.This review summarizes the research progress of double-layer tablets in recent years,generalizes the characteristics,preparation methods and classification of double-layer tablets,and introduces its clinical applications with case studies.It is hoped to provide a reference for the research and development of double-layer tablets.

关 键 词：双层片 速释层 缓释层 药效 固体制剂 

分 类 号：R944.4[医药卫生—药剂学]