脑可塑性在运动改善抑郁中的作用分析  

Analysis of the role of brain plasticity in improvements in depression

作　　者：陈祥和[1] 陆鹏程 沈梓铭 刘驰 曾炘瑜 殷荣宾[3] CHEN Xianghe;LU Pengcheng;SHEN Ziming;LIU Chi;ZENG Xinyu;YIN Rongbin(College of Physical Education,Yangzhou University,Yangzhou 225127,China;Yancheng Marine Vocational School,Yancheng 224100;Physical Education and Sports School of Soochow University,Suzhou 215021)

机构地区：[1]扬州大学体育学院,江苏扬州225127 [2]盐城海洋职业学校,江苏盐城224100 [3]苏州大学体育学院,江苏苏州215021

出　　处：《中国比较医学杂志》2024年第4期165-174,共10页Chinese Journal of Comparative Medicine

基　　金：江苏省哲学社会科学基金项目(20TYC001)。

摘　　要：抑郁发生的作用机制研究是当前神经科学领域的焦点,脑可塑性退化(海马、前额叶、扣带回等体积变小、结构退化及功能紊乱)导致抑郁。运动作为改善抑郁的重要手段,当前研究证实了海马、前额叶、扣带回等体积、结构及功能改善在此过程中的重要机制,但相关研究成果仅是单独聚焦于某一脑体积或连接功能变化,缺少较为全面、系统的分析脑可塑性改善在运动抗抑郁中作用机制的研究。因此,本研究拟从抑郁发生及运动改善抑郁两个方面展开,揭示脑可塑性在其中所扮演角色。这有助于全面理解脑可塑性在运动改善抑郁发生中的作用,也将为运动干预抑郁提供新思路。Research on the mechanisms of depression is currently a focus of the field of neuroscience.The degeneration of brain plasticity(e.g.,decrease in volume,structural degradation,and functional disorder of the hippocampus,PFC,and CG)leads to depression.Exercise is an important means of improving the symptoms of depression.Current research confirms the importance of improving the volume,structure,and function of the hippocampus,PFC,and CG,in this process,but related research has focused solely on changes to the volume of certain brain regions or connectivity functions.Thus,we lack a comprehensive understanding of the antidepressant mechanisms that improve brain plasticity with exercise.Therefore,this study aimed to explore the roles of brain plasticity in the occurrence of depression and improvements to depression through exercise,promoting a more comprehensive understanding the role of brain plasticity in depression.We also provide new ideas for exercise intervention in depression.

关 键 词：脑可塑性 运动 抑郁 脑结构 脑功能 

分 类 号：R-33[医药卫生]