硫化氢与神经炎症介导的神经退行性疾病  

Hydrogen sulfide and neuroinflammation-mediated neurodegenerative diseases

作　　者：税玉莲 任治琼 何怡洁 陈缤彬 洪嘉 刘柯婷 肖莉[5] SHUI Yu-lian;REN Zhi-qiong;HE Yi-jie;CHEN Bin-bin;HONG Jia;LIU Ke-ting;XIAO Li(Anesthesiology Major,Grade 2020,Chengdu Medical College,Chengdu Sichuan 610500,China;Anesthesiology Major,Grade 2021,Chengdu Medical College,Chengdu Sichuan 610500,China;Anesthesiology Major,Grade 2019,Chengdu Medical College,Chengdu Sichuan 610500,China;Department of Neurology,Chengdu Seventh People´s Hospital,Chengdu Sichuan 610200,China;Department of Human Anatomy,Chengdu Medical College/Development and Regeneration Key Laboratory of Sichuan Province,Chengdu Sichuan 610500,China)

机构地区：[1]成都医学院2020级麻醉学专业,四川成都610500 [2]成都医学院2021级麻醉学专业,四川成都610500 [3]成都医学院2019级麻醉学专业,四川成都610500 [4]成都市第七人民医院神经内科,四川成都610200 [5]成都医学院人体解剖学教研室/发育与再生四川省重点实验室,四川成都610500

出　　处：《局解手术学杂志》2024年第6期551-554,共4页Journal of Regional Anatomy and Operative Surgery

基　　金：四川省大学生创新实验项目(202313705013,202213705031,S202113705079,S201913705054);2022年成都市医学科研课题(2022307);成都医学院-成都市第七人民医院联合科研基金项目(2021LHJYPJ-07,23LHQYZ-01)。

摘　　要：硫化氢作为第3种气体信号分子和神经递质,可通过抗氧化应激、抗炎症反应、代谢抑制等机制发挥神经保护作用,对神经炎症介导的阿尔兹海默病(AD)、帕金森病(PD)等神经退行性疾病的发生发展具有重要意义。本文对硫化氢与神经炎症及其介导的神经退行性疾病的相关研究进展进行综述,以期为神经退行性疾病的治疗提出新的思路。Hydrogen sulfide,as a third gas signal molecule and neurotransmitter,can play a neuroprotective role by anti-oxidative stress,anti-inflammatory response,metabolic inhibition and other mechanisms.It is of great significance for the occurrence and development of neurodegenerative diseases including Alzheimer´s disease(AD)and Parkinson´s disease(PD)mediated by neuroinflammation.This article reviews the research progress of hydrogen sulfide and neuroinflammation and its mediated neurodegenerative diseases,so as to provide new ideas for the treatment of neurodegenerative diseases.

关 键 词：硫化氢 神经炎症 神经退行性疾病 

分 类 号：R742[医药卫生—神经病学与精神病学]