Relationships between blood chromium exposure and liver injury:Exploring the mediating role of systemic inflammation in a chromate-exposed population  

作　　者：Zekang Su Yali Zhang Shiyi Hong Qiaojian Zhang Jiayu Xu Guiping Hu Xiaojun Zhu Fang Yuan Shanfa Yu Tianchen Wang Guang Jia 

机构地区：[1]Department of Occupational and Environmental Health Sciences,School of Public Health,Peking University,Beijing 100191,China [2]School of Engineering Medicine and Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Beihang University,Beijing 100191,China [3]National Center for Occupational Safety and Health,Beijing 102308,China [4]Department of Occupational Health and Radiological Health,Chongqing Centers for Disease Control and Prevention,Chongqing 400042,China [5]Henan Institute for Occupational Medicine,Zhengzhou 450052,China [6]Department of Clinical Laboratory,Third Hospital of Peking University,Beijing 100191,China

出　　处：《Journal of Environmental Sciences》2024年第9期224-234,共11页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82273603,82003427,U2004202)。

摘　　要：Hexavalent chromium and its compounds are prevalent pollutants,especially in the work environment,pose a significant risk for multisystem toxicity and cancers.While it is known that chromium accumulation in the liver can cause damage,the dose-response relationship between blood chromium(Cr)and liver injury,as well as the possible potential toxic mechanisms involved,remains poorly understood.To address this,we conducted a follow-up study of 590 visits from 305 participants to investigate the associations of blood Cr with biomarkers for liver injury,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),and direct bilirubin(DBIL),and to evaluate the mediating effects of systemic inflammation.Platelet(PLT)and the platelet-to-lymphocyte ratio(PLR)were utilized as biomarkers of systemic inflammation.In the linear mixed-effects analyses,each 1-unit increase in blood Cr level was associated with estimated effect percentage increases of 0.82%(0.11%,1.53%)in TBIL,1.67%(0.06%,3.28%)in DBIL,0.73%(0.04%,1.43%)in ALT and 2.08%(0.29%,3.87%)in AST,respectively.Furthermore,PLT mediated 10.04%,11.35%,and 10.77%increases in TBIL,DBIL,and ALT levels induced by chromate,respectively.In addition,PLR mediated 8.26%and 15.58%of the association between blood Cr and TBIL or ALT.These findings shed light on the mechanisms underlying blood Cr-induced liver injury,which is partly due to worsening systemic inflammation.

关 键 词：Blood chromate Liver injury Systemic inflammation Mediation analysis 

分 类 号：R575[医药卫生—消化系统] X503.1[医药卫生—内科学]