Glutamicibacter nicotianae AT6:A new strain for the efficient biodegradation of tilmicosin  

作　　者：Huijuan Li Hao Zhou Liling Fan Long Meng Yanyun Zhao Lanmei Zhao Bo Wang 

机构地区：[1]College of Chemical and Biological Engineering,Shandong University of Science and Technology,Qingdao 266590,China [2]College of Chemistry and Chemical Engineering,Heze University,Heze 274015,China [3]College of Safety and Environmental Engineering,Shandong University of Science and Technology,Qingdao 266590,China

出　　处：《Journal of Environmental Sciences》2024年第8期182-192,共11页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.21868011,42106144,42077444);the National Key R&D Program of China(No.2017YFC1103800);the financial support from Shandong University of Science and Technology(No.SKR19-1-012)。

摘　　要：The degradation of tilmicosin(TLM),a semi-synthetic 16-membered macrolide antibiotic,has been receiving increasing attention.Conventionally,there are three tilmicosin degradation methods,and among them microbial degradation is considered the best due to its high efficiency,eco-friendliness,and low cost.Coincidently,we found a new strain,Glutamicibacter nicotianae sp.AT6,capable of degrading high-concentration TLM at 100 mg/L with a 97%removal efficiency.The role of tryptone was as well investigated,and the results revealed that the loading of tryptone had a significant influence on TLM removals.The toxicity assessment indicated that strain AT6 could efficiently convert TLM into less-toxic substances.Based on the identified intermediates,the degradation of TLM by AT6 processing through two distinct pathways was then proposed.

关 键 词：TILMICOSIN Glutamicibacter nicotianae BIODEGRADATION Degradation pathway Pharmaceutical wastewater 

分 类 号：X172[环境科学与工程—环境科学]