帕金森病睡眠障碍多导睡眠监测及血清5-HT研究  

Polysomnography and serum 5-HT study on Parkinson’s disease sleep disorder

作　　者：吴越庐 安竹燕 吴碧雯 蔡佳烨 俞垭美 冯兴刚 WU Yuelu;AN Zhuyan;WU Biwen;CAI Jiaye;YU Yamei;FENG Xinggang(Department of Neurology,the 903rd Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army,Hangzhou 310004,Zhejiang,China;Department of Neurology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,Zhejiang,China)

机构地区：[1]中国人民解放军联勤保障部队第九〇三医院神经内科,浙江杭州310004 [2]浙江大学医学院附属邵逸夫医院神经内科,浙江杭州310016

出　　处：《中国现代医生》2024年第15期63-66,共4页China Modern Doctor

基　　金：浙江省基础公益研究计划(LGF22H090011)。

摘　　要：目的探究帕金森病患者睡眠障碍与多导睡眠监测参数及血清5-羟色胺(5-hydroxytryptamine,5-HT)水平的关系。方法收集2021年7月至2023年6月浙江大学医学院附属邵逸夫医院收治的80例帕金森病患者,根据匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分分为研究组(n=46,PSQI评分>10分)和对照组(n=34,PSQI评分≤10分),对两组患者行整夜多导睡眠监测,检测血清5-HT水平,比较两组多导睡眠监测参数及血清5-HT水平,并分析睡眠障碍与多导睡眠监测参数及血清5-HT水平的相关性。结果研究组患者的总睡眠时间显著短于对照组,睡眠效率和最低血氧饱和度均显著低于对照组(P<0.05);研究组患者的血清5-HT水平显著低于对照组(P<0.05)。相关性分析显示PSQI评分与总睡眠时间、睡眠效率、最低血氧饱和度和血清5-HT水平均呈负相关(P<0.05)。结论帕金森病患者的睡眠障碍与总睡眠时间减少、睡眠效率下降、最低血氧饱和度降低和血清5-HT水平降低具有相关性。Objective To explore the relationship between sleep disorders and polysomnography parameters and serum 5-hydroxytryptamine(5-HT)levels in Parkinson’s disease patients.Methods 80 Parkinson’s disease patients admitted of Sir Run Run Shaw Hospital,Zhejiang University School of Medicine from July 2021 to June 2023 were collected,and based on the Pittsburgh sleep quality index(PSQI)score divided them into study group(n=46,PSQI>10 points)and control group(n=34,PSQI≤10 points).Overnight polysomnography monitoring on two groups of patients was conducted,serum 5-HT levels were detected,polysomnography parameters and serum 5-HT levels between two groups were compared,and the correlation between sleep disorders and polysomnography parameters and serum 5-HT levels were analyzed.Results The total sleep time of study group was significantly shorter than that of control greup,sleep efficiency,and minimum blood oxygen saturation of study group were significantly lower than those of control group(P<0.05).The serum 5-HT levels in study group were significantly lower than those in control group(P<0.05).Correlation analysis showed that the PSQI score was negatively correlated with total sleep time,sleep efficiency,minimum blood oxygen saturation,and serum 5-HT levels(P<0.05).Conclusion Sleep disorders in Parkinson’s disease patients are associated with decreased total sleep time,sleep efficiency,minimum blood oxygen saturation and serum 5-HT levels.

关 键 词：帕金森病 睡眠障碍 多导睡眠监测参数 5-羟色胺 

分 类 号：R742.5[医药卫生—神经病学与精神病学]