重复经颅磁刺激联合丁苯酞治疗缺血性脑卒中后认知障碍的效果  

The Effect of Repeated Transcranial Magnetic Stimulation Combined with Butylphthalide in the Treatment of Cognitive Impairment after Ischemic Stroke

作　　者：李蓓蓓 刘洁琼[1] 程非 李厚英[1] 窦长新 LI Beibei;LIU Jieqiong;CHENG Fei;LI Houying;DOU Changxin(Department of Neurology,Zoucheng People's Hospital,Zoucheng 273500,China)

机构地区：[1]邹城市人民医院神经内科,山东邹城273500

出　　处：《中国医学创新》2024年第14期10-13,共4页Medical Innovation of China

摘　　要：目的:探析缺血性脑卒中后认知障碍患者行重复经颅磁刺激联合丁苯酞治疗干预的临床效果及对神经、认知功能的影响。方法:择取邹城市人民医院收治的96例缺血性脑卒中后认知障碍患者为样本,研究时间跨度为2021年6月—2023年6月,采用随机数字表法将患者分为研究组(n=48)、对照组(n=48)。两组患者均行脑卒中基础治疗,对照组增加丁苯酞治疗,研究组增加重复经颅磁刺激联合丁苯酞治疗。比较两组蒙特利尔认知评估(MoCA)评分、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数、简易智力状态检查(MMSE)评分、临床效果。结果:治疗后,研究组MoCA评分高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组NIHSS评分低于对照组,Barthel指数高于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组MMSE评分高于对照组,差异有统计学意义(P<0.05)。研究组临床总有效率高于对照组,差异有统计学意义(P<0.05)。结论:缺血性脑卒中后认知障碍患者行重复经颅磁刺激联合丁苯酞治疗可改善认知功能及神经功能,提升日常生活能力,改善智力状态,临床效果显著。Objective:To explore the clinical effect of repeated transcranial magnetic stimulation combined with Butolphthalide treatment intervention on cognitive impairment patients after ischemic stroke and its effect on neurological and cognitive function.Method:A sample of 96 patients with cognitive patients after ischemic stroke in Zoucheng People's Hospital,the study period from June 2021 to June 2023,was divided into study group(n=48)and control group(n=48)by random number table method.Both groups of patients received basic treatment for stroke,the control group received additional treatment with Butylphthalide,the study group received additional treatment with repeated transcranial magnetic stimulation combined with Butylphthalide.Montreal cognitive assessment(MoCA)scores,national institutes of health stroke scale(NIHSS)scores,Barthel index,mini mental state examination(MMSE)scores,and clinical effects of two groups were compared.Result:After treatment,the MoCA score of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the NIHSS score of the study group was lower than that of the control group,and the Barthel index was higher than that of the control group,the differences were statistically significant(P<0.05).After treatment,the MMSE score of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).The total clinical effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Repeated transcranial magnetic stimulation combined with Butyphthalide on incognitive impairment patients after ischemic stroke can improve cognitive function and neurological function,improve daily living ability,which has remarkable clinical effect.

关 键 词：重复经颅磁刺激 丁苯酞 缺血性脑卒中 认知障碍 

分 类 号：R743.3[医药卫生—神经病学与精神病学]