rTMS联合舍曲林对首发抑郁症伴躯体疼痛青少年患者认知功能的影响  

Effect of rTMS Combined with Sertraline on Cognitive Function in Adolescent Patients with First-episode Depression and Somatic Pain

作　　者：李明锋 钟琼 LI Mingfeng;ZHONG Qiong(Department of Psychosomatic Medicine,the Third People's Hospital of Ganzhou,Ganzhou 341000,China)

机构地区：[1]赣州市第三人民医院心身医学科,江西赣州341000

出　　处：《中国医学创新》2024年第14期82-86,共5页Medical Innovation of China

基　　金：赣州市指导性科技计划项目(20222ZDX9785)。

摘　　要：目的:探究重复经颅磁刺激(rTMS)联合舍曲林应用于首发抑郁症伴躯体疼痛的青少年患者认知功能的效果。方法:选取2022年10月—2023年9月赣州市第三人民医院收治的首发抑郁症伴躯体疼痛青少年共计80例,采用随机数字表法将上述研究对象分为观察组(n=40)及对照组(n=40)。对照组接受舍曲林治疗,观察组在对照组方案的基础之上联合rTMS进行治疗。记录并比较两组治疗效果、数字评价量表(NRS)评分、汉密尔顿抑郁量表-17项(HAMD-17)评分、汉密尔顿焦虑量表(HAMA)评分、蒙特利尔认知评估量表(MoCA)评分、临床记忆量表(CMS)评分及不良反应发生率。结果:观察组治疗总有效率为95.00%,显著高于对照组的77.50%(P<0.05)。治疗后,两组NRS、HAMD-17、HAMA评分相比治疗前均降低,且观察组均低于对照组(P<0.05);两组MoCA评分、CMS评分相比治疗前均升高,且观察组均高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:rTMS联合舍曲林治疗能够缓解青少年抑郁症患者躯体疼痛、改善认知功能。Objective:To explore the effects of repetitive transcranial magnetic stimulation(rTMS)combined with Sertraline on cognitive function in adolescents with first-episode depression and somatic pain.Method:A total of 80 adolescents with first-episode depression and somatic pain admitted to the Third People's Hospital of Ganzhou were enrolled from October 2022 to September 2023.According to random number table method,they were divided into observation group(n=40)and control group(n=40).The control group was treated with Sertraline,while observation group was additionally treated with rTMS.Clinical effect,scores of numerical rating scale(NRS),Hamilton depression scale 17-item(HAMD-17),Hamilton anxiety scale(HAMA),Montreal cognitive assessment(MoCA)and clinical memory scale(CMS),and the incidence of adverse reactions in the two groups were recorded and compared.Result:The total effective rate of treatment in observation group was 95.00%,which was significantly higher than 77.50%in control group(P<0.05).After treatment,scores of NRS,HAMD-17 and HAMA in both groups were decreased compared to those before treatment,those in the observation group were lower than those in control group(P<0.05);the scores of MoCA and CMS in both groups were increased compared to those before treatment,those in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:rTMS combined with Sertraline can relieve somatic pain and improve cognitive function in adolescents with depression.

关 键 词：首发抑郁症 重复经颅磁刺激 舍曲林 躯体疼痛 认知功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学]