盐酸哌罗匹隆联合丁螺环酮治疗难治性精神分裂症的临床研究  

Clinical Study of Perospirone Hydrochloride Combined with Buspirone in the Treatment of Refractory Schizophrenia

作　　者：刘世坚 LIU Shijian(Department of Psychiatry,Fuzhou Third Hospital,Fuzhou 344000,China)

机构地区：[1]抚州市第三医院精神科,江西抚州344000

出　　处：《中国医学创新》2024年第15期59-62,共4页Medical Innovation of China

基　　金：抚州市指导性科技计划项目(抚科社字【2022】9号序号71)。

摘　　要：目的:探究盐酸哌罗匹隆联合丁螺环酮治疗难治性精神分裂症的临床效果。方法:将2021年6月—2022年12月抚州市第三医院收治的82例难治性精神分裂症患者根据随机数字表法分为两组。对照组(n=41)采用利培酮联合丁螺环酮进行治疗,观察组(n=41)采用盐酸哌罗匹隆联合丁螺环酮进行治疗。比较两组治疗总有效率、不良反应总发生率,以及治疗前后的阳性和阴性精神症状评定量表(PANSS)评分及社会功能缺陷筛选量表(SDSS)评分。结果:观察组治疗总有效率显著高于对照组,不良反应总发生率显著低于对照组(P<0.05);治疗前两组PANSS评分及SDSS评分比较,差异均无统计学意义(P>0.05);治疗6、12周后观察组PANSS评分及SDSS评分均显著低于对照组(P<0.05)。结论:盐酸哌罗匹隆联合丁螺环酮治疗难治性精神分裂症的临床效果较好,安全性较高,可更为显著地改善患者的社会功能。Objective:To investigate the clinical effect of Perospirone Hydrochloride combined with Buspirone in the treatment of refractory schizophrenia.Method:A total of 82 patients with refractory schizophrenia admitted to Fuzhou Third Hospital from June 2021 to December 2022 were divided into two groups according to random number table method.The control group(n=41)was treated with Risperidone combined with Buspirone,and the observation group(n=41)was treated with Perospirone Hydrochloride combined with Buspirone.The total effective rate,total incidence of adverse reactions and positive and negative syndrome scale(PANSS)scores and strategic decision support system(SDSS)scores before and after treatment were compared between the two groups.Result:The total effective rate of treatment in observation group was significantly higher than that in control group,and the total incidence of adverse reactions was significantly lower than that in control group(P<0.05).There were no significant differences in PANSS scores and SDSS scores between the two groups before treatment(P>0.05).After 6 and 12 weeks of treatment,PANSS scores and SDSS scores in observation group were significantly lower than those in control group(P<0.05).Conclusion:Perospirone Hydrochloride combined with Buspirone in the treatment of refractory schizophrenia has good clinical effect and high safety,which can significantly improve the social function of patients.

关 键 词：盐酸哌罗匹隆 丁螺环酮 难治性精神分裂症 社会功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]