基于软光刻的高分子生物材料表面图案化及改性研究进展  

Research progress of surface patterning and modification of polymer biomaterials based on soft lithography

作　　者：管馨 翁鑫泽 赖颖真 郑晓丹 GUAN Xin;WENG Xinze;LAI Yingzhen;ZHENG Xiaodan(Department of StomatologyEngineering Research Center of Fujian University for Stomatological Biomaterials,Xiamen Medical College,Fujian Province,Xiamen 361023,China)

机构地区：[1]厦门医学院口腔医学系,口腔生物材料福建省高校工程研究中心,福建厦门361023

出　　处：《中国医药导报》2024年第11期184-186,共3页China Medical Herald

基　　金：大学生创新创业训练计划项目(国家级)(202312631004);福建省自然科学基金面上项目(2022J011408);福建省中青年教师教育科研项目(科技类)(JAT210489)。

摘　　要：生物材料表面的微形貌通过模仿细胞外基质,对细胞的行为具有调控作用。本文基于聚二甲基硅氧烷软光刻技术,分析热塑性和非热塑性材料的理化和生物特性,阐述如何分别采用熔融浇铸和溶液浇注的方法进行单一或复合表面图案化制备,探讨如何通过图案特性对组织工程细胞生物学行为产生影响。此外借鉴热塑性材料改性方法(表面化学修饰、表面微纳米级形貌修饰、表面生物涂层修饰)探讨如何在热塑性图案化结构的基础上赋予材料新的生物功能,为高分子生物材料表面的图案化和改性研究提供参考。The micromorphology of the surface of biomaterials can regulate the behavior of cells by imitating extracellular matrix.Based on polydimethylsiloxane soft lithography,the physicochemical and biological properties of thermoplastic and non-thermoplastic materials are analyzed,how to fabricate single or composite surfaces patterning by melt casting and solution casting respectively is described,and how to influence the biological behavior of tissue engineering cells through the pattern characteristics is discussed.In addition,by referring to the modification methods of thermoplastic materials(surface chemical modification,surface micro-nano morphology modification,and surface biological coating modification),the paper discusses how to endow the materials with new biological functions on the basis of the thermoplastic patterning structure,and provides a reference for the research on the patterning and modification of the surface of polymer biomaterials.

关 键 词：图案化 软光刻 高分子生物材料 改性 

分 类 号：R318.08[医药卫生—生物医学工程]