新生儿呼吸窘迫综合征患儿血清HMGB1、RAGE、BMP-7表达及与肺部超声评分的相关性  

Expression of serum HMGB1,RAGE and BMP-7 in children with neonatal respiratory distress syndrome and their correlation with lung ultrasound score

作　　者：鲁旭 刘丹 LU Xu;LIU Dan(Pediatrics Department,Xianyang Central Hospital,Xianyang 712000,China)

机构地区：[1]咸阳市中心医院儿科,陕西咸阳712000

出　　处：《临床医学研究与实践》2024年第17期87-90,共4页Clinical Research and Practice

摘　　要：目的 分析新生儿呼吸窘迫综合征(NRDS)患儿血清高迁移率族蛋白1(HMGB1)、晚期糖基化终末产物受体(RAGE)、骨形态发生蛋白-7(BMP-7)表达及与肺部超声评分的相关性。方法 选择2018年6月至2023年6月收治的100例NRDS患儿纳入观察组,同期选择100例健康新生儿纳入对照组,均进行血清HMGB1、RAGE、BMP-7检测和肺部超声检查及评分。根据NRDS患儿肺部超声评分将其分为低评分组(评分<12分)、中评分组(评分12~24分)及高评分组(评分>24分)。比较两组研究对象的血清HMGB1、RAGE、BMP-7水平和肺部超声评分;比较不同肺部超声评分患儿的血清HMGB1、RAGE、BMP-7水平;分析观察组中血清HMGB1、RAGE、BMP-7表达与肺部超声评分的相关性。结果 观察组的血清HMGB1、RAGE及BMP-7水平及肺部超声评分高于对照组(P<0.05)。肺部超声显示低评分组47例,中评分组33例,高评分组20例;低评分组的血清HMGB1、RAGE及BMP-7水平低于中评分组和高评分组(P<0.05);中评分组的血清HMGB1、RAGE及BMP-7水平低于高评分组(P<0.05)。Spearman相关性分析结果显示,血清HMGB1、RAGE、BMP-7表达与肺部超声评分呈正相关(P<0.05)。结论 NRDS患儿血清HMGB1、RAGE、BMP-7表达及肺部超声评分均会明显增高,血清HMGB1、RAGE、BMP-7表达与肺部超声评分呈正相关。Objective To analyze the expression of serum high mobility group box-1 protein(HMGB1),receptor of advanced glycation endproducts(RAGE)and bone morphogenetic protein-7(BMP-7)in children with neonatal respiratory distress syndrome(NRDS)and their correlation with lung ultrasound score.Methods A total of 100 children with NRDS admitted from June 2018 to June 2023 were selected as observation group,and 100 healthy newborns were selected as control group at the same time.Serum HMGB1,RAGE,BMP-7 detection and lung ultrasound examination and score were performed.According to the lung ultrasound score of NRDS children,the children were divided into low score group(score<12 points),middle score group(score 12-24 points),and high score group(score>24 points).The levels of serum HMGB1,RAGE,BMP-7 and lung ultrasound score were compared between the two groups;the levels of serum HMGB1,RAGE and BMP-7 in children with different lung ultrasound scores were compared;the correlation between serum HMGB1,RAGE,BMP-7 expression and lung ultrasound score in the observation group was analyzed.Results The levels of serum HMGB1,RAGE and BMP-7 and lung ultrasound score in the observation group were higher than those in the control group(P<0.05).Lung ultrasound showed 47 cases in the low score group,33 cases in the middle score group,and 20 cases in the high score group;the levels of serum HMGB1,RAGE and BMP-7 in the low score group were lower than those in the middle score group and the high score group(P<0.05);the levels of serum HMGB1,RAGE and BMP-7 in the middle score group were lower than those in the high score group(P<0.05).Spearman correlation analysis showed that the expression of serum HMGB1,RAGE and BMP-7 was positively correlated with lung ultrasound score(P<0.05).Conclusion The expression of serum HMGB1,RAGE,BMP-7 and lung ultrasound score in children with NRDS significantly increase,the expression of serum HMGB1,RAGE and BMP-7 are positively correlated with lung ultrasound score.

关 键 词：新生儿呼吸窘迫综合征 高迁移率族蛋白1 晚期糖基化终末产物受体 骨形态发生蛋白-7 肺部超声评分 

分 类 号：R742.1[医药卫生—神经病学与精神病学]