人表皮生长因子滴眼液对白内障患者晶状体超声乳化术后干眼症的效果  

Effect of human epidermal growth factor eye drops on dry eye after phacoemulsification in cataract patients

作　　者：曾令岩 李英俊 张蕾 夏丹 郭彬 ZENG Lingyan;LI Yingjun;ZHANG Lei;XIA Dan;GUO Bin(Department of Ophthalmology,Fuyang People’s Hospital,Anhui Province,Fuyang 236000,China)

机构地区：[1]安徽省阜阳市人民医院眼科,安徽阜阳236000

出　　处：《中国医药导报》2024年第12期107-110,共4页China Medical Herald

摘　　要：目的 探讨人表皮生长因子滴眼液对白内障患者晶状体超声乳化术(PHACO)术后干眼症的效果。方法 选取2023年1月至10月安徽省阜阳市人民医院收治的90例白内障PHACO术后干眼症患者为研究对象,按照随机数字表法分成对照组和观察组,各45例。对照组予以聚乙烯醇滴眼液治疗,观察组在对照组基础上加用人表皮生长因子滴眼液治疗。用药4周后,比较两组疗效、泪河高度、泪膜稳定性、视觉质量及不良反应发生情况。结果 观察组疗效优于对照组(P<0.05)。治疗后,两组泪膜破裂时间(BUT)长于治疗前,角膜荧光素染色实验(FL)、眼表疾病指数(OSDI)、标准干眼症状评估量表(SPEED)评分低于治疗前,泪河高度、基础泪液分泌实验(LST)高于治疗前,且观察组BUT长于对照组,FL、OSDI、SPEED评分低于对照组,泪河高度、LST高于对照组(P<0.05)。两组均未见明显不良反应。结论 聚乙烯醇滴眼液联合人表皮生长因子滴眼液用于白内障PHACO术后干眼症患者临床治疗,可通过改善泪河高度及泪膜稳定性,提升效果,并提高患者视觉质量,且用药安全。Objective To explore the effect of Human Epidermal Growth Factor Eye Drops on dry eye after phacoemulsification(PHACO) in cataract patients.Methods Ninety patients with postoperative dry eye syndrome after PHACO admitted to Fuyang People's Hospital,Anhui Province from January to October 2023 were selected as the study subjects.They were divided into the control group and the observation group by using the random number table method,with45 cases in each group.The control group was treated with Polyvinyl Alcohol Eye Drops,while observation group was treated with Human Epidermal Growth Factor Eye Drops in addition.Four weeks after medication,the efficacy,tear stream height,tear film stability,visual quality,and incidence of adverse reactions between two groups were compared.Results The effect of observation group was better than that of control group(P<0.05).After treatment,break-up time(BUT) of two groups were longer than that before treatment,fluorescein staining(FL),ocular surface disease index(OSDI),and standard patient evaluation of eye dryness(SPEED) scores of two groups were lower than those before treatment,and the tear river height and lacrimal secretion test(LST) of two groups were higher than those before treatment,and BUT of observation group were longer than that of control group,FL,OSDI,and SPEED scores of observation group were lower than those of control group,and the tear river height and LST of observation group were higher than those of control group(P<0.05).No significant adverse reactions were observed in two groups.Conclusion Polyvinyl Alcohol Eye Drops combined with Human Epidermal Growth Factor Eye Drops for the clinical treatment of patients with dry eye after cataract PHACO surgery can improve the therapeutic effect and the visual quality of patients by improving the height of tear river and the stability of tear film,and the drug is safe.

关 键 词：晶状体超声乳化术 干眼症 聚乙烯醇滴眼液 重组人表皮生长因子滴眼液 泪膜稳定性 泪河高度 

分 类 号：R771[医药卫生—眼科]