丁苯酞联合盐酸多奈哌齐治疗卒中后认知功能损害患者的临床疗效观察  

Clinical Efficacy Observation of Butylphthalein Combined with Donepezil Hydrochloride in the Treatment of Post-stroke Patients with Cognitive Impairment

作　　者：许宏侠 张晨露 刘欣欣[1] XU Hong-xia;ZHANG Chen-lu;LIU Xin-xin(Department of Geriatrics,the First Affiliated Hospital of Henan University,Kaifeng 475001,China)

机构地区：[1]河南大学第一附属医院老年病科,开封475001

出　　处：《四川解剖学杂志》2024年第1期69-72,共4页Sichuan Journal of Anatomy

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHCJ20190505)。

摘　　要：目的:探讨丁苯酞联合盐酸多奈哌齐治疗卒中后认知功能损害患者的临床疗效.方法:选取2020年2月至2022年12月于本院治疗的88例卒中后并发认知功能损害患者为研究对象.根据药物治疗方案不同将其分为观察组(n=46,采用丁苯酞联合盐酸多奈哌齐治疗)和对照组(n=42,仅采用盐酸多奈哌齐治疗).两组患者治疗总疗效、蒙特利尔认知评估量表(MoCA)评分、日常生活活动能力量表(BI)、血清因子水平及安全性进行统计学分析.结果:观察组患者治疗总有效率为91.30%,显著高于对照组的73.81%,差异有统计学意义(P<0.05).治疗后,两组MoCA评分、BI均较治疗前上升,且观察组MoCA评分、BI上升幅度均大于对照组,差异均有统计学意义(P<0.05);血清超敏C反应蛋白(hs-CRP)、神经元特异性烯醇化酶(NSE)及丙二醛(MDA)水平,均较治疗前显著下降,且观察组血清hs-CRP、NSE及MDA水平,显著低于对照组,差异均有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:丁苯酞联合盐酸多奈哌齐治疗卒中后认知功能损害患者总有效率高于仅采用盐酸多奈哌齐治疗,可改善患者认知功能、日常生活能力,且机体炎症反应减轻.Objective:To explore the clinical efficacy of butylphthalein plus Donepezil hydrochloride in the treatment of post-stroke patients with cognitive impairment.Methods:Eighty-eight patients with post-stroke cognitive impairment treated in our hospital from February 2020 to December 2022 were selected as the study subjects,and they were divided into observation group(n=46,treated with buphthalein combined with Donepezil hydrochloride)and control group(n=42,treated with Donepezil hydrochloride only)according to different drug regimens.Compare the total efficacy,Montreal cognitive assessment scale(MoCA),Barthel index(BI),serum factors,and safety between two groups.Results:The total efficacy rates of the observation group(91.30%)was higher than that of the control group(73.81%),and the difference was statistically significant(P<0.05).After treatment,MoCA score and Barthel index increased in the two groups,and the increase rate of MoCA score and BI in observation group was greater than that in control group,with statistical significance(P<0.05).After treatment,the levels of serum hypersensitive C-reactive protein(hs-CRP),neuron specific enolase(NSE)and Malondialdehyde(MDA)in the two groups significantly decreased,and serum hs-CRP,NSE and MDA levels in observation group were lower than those in control group,with statistical significance(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Butylphthalein combined with Donepezil hydrochloride in the treatment of post-stroke patients with cognitive impairment has a high overall effect,which can improve the cognitive function and daily living ability of patients,and reduce the body inflammatory response.

关 键 词：丁苯酞 盐酸多奈哌齐 卒中 认知功能损害 临床疗效 

分 类 号：R743.3[医药卫生—神经病学与精神病学]