脑小血管病与胰岛素抵抗相关性的研究进展  

Research progress on the relationship between cerebral small vessel disease and insulin resistance

作　　者：王磊[1,2] 张保朝 WANG Lei;ZHANG Baochao(Graduate School of Xinxiang Medical College,Xinxiang,Henan 453000,China;Department of Neurology,Nanyang Central Hospital,Nanyang,Henan 473000,China)

机构地区：[1]新乡医学院研究生院,河南省新乡市453000 [2]南阳市中心医院神经内科,河南省南阳市473000

出　　处：《中国动脉硬化杂志》2024年第6期547-552,共6页Chinese Journal of Arteriosclerosis

基　　金：河南省科技发展计划(202102310079)。

摘　　要：脑小血管病(CSVD)指各种病因影响脑小血管所导致的一系列临床影像病理综合征,具有起病隐匿、发病率高、易复发的特点。胰岛素抵抗(IR)是指机体对胰岛素的敏感性降低。近年来,越来越多的研究证实IR与CSVD的影像学特征的发生发展相关,但机制尚不明确。本文就IR与CSVD的关系的研究及可能机制进行综述,以期为脑小血管病的防治提供参考。Cerebral small vessel disease(CSVD)refers to a series of clinical imaging pathological syndromes caused by various etiologies affecting cerebral small vessels,which have the characteristics of insidious onset,high incidence and easy recurrence.Insulin resistance(IR)is a decrease in the body's sensitivity to insulin.In recent years,more and more studies have confirmed that IR is associated with the occurrence and development of imaging features of CSVD,but the mechanism is still unclear.This article reviews the relationship between IR and cerebral small vessel disease and its possible mechanism,in order to provide reference for the prevention and treatment of cerebral small vessel disease.

关 键 词：脑小血管病 胰岛素抵抗 神经影像学 内皮功能障碍 动脉粥样硬化 炎症 

分 类 号：R743.3[医药卫生—神经病学与精神病学]