口服秋水仙碱引起血清CA72-4升高的初步研究  

Preliminary Study of Elevated Serum CA72-4 Caused by Oral Colchicine

作　　者：范海波[1] 张静[1] 王志国[1] 施建丰[1] 赵巧燕 姚孝明[1] 杨婉薇[1] FAN Hai-bo;ZHANG-Jing;WANG Zhi-guo;SHI Jian-feng;ZHAO Qiao-yan;YAO Xiao-ming;YANG Wan-wei(Department of Clinical Laboratory,Affiliated Hospital of Integrated Chinese and Western Medicine,Nanjing University of Traditional Chinese Medicine/Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China)

机构地区：[1]南京中医药大学附属中西医结合医院,江苏省中医药研究院检验科,江苏南京210028

出　　处：《药物生物技术》2024年第1期81-84,共4页Pharmaceutical Biotechnology

摘　　要：探讨口服秋水仙碱引起血清CA72-4升高的原因。结合口服秋水仙碱引起非肿瘤患者血清CA72-4增高的病例,通过细胞实验探讨秋水仙碱对胃癌细胞BGC-823 CA72-4分泌的影响,通过体外秋水仙碱和血清共处理,明确秋水仙碱是否直接干扰血清CA72-4的测定。不同浓度(0、0.5、5、50μg/L)的秋水仙碱处理胃癌细胞BGC-82324 h后,各组细胞上清液CA72-4的浓度差别无统计学意义。秋水仙碱与患者血清体外共处理1、2和3 h后,各组血清CA72-4的浓度差别无统计学意义。CA72-4是指示胃癌的肿瘤标志物之一,但胃癌细胞中CA72-4的产生机制尚不完全清楚,秋水仙碱引起CA72-4升高的机制也未被完全阐明,临床医生和检验医生应考虑药物因素可能引起的血清CA72-4浓度的改变。To explore the cause of increased serum CA72-4 induced by oral colchicine,combined with the cases of elevated serum CA72-4 in non-tumor patients,the effect of colchicine on the secretion of CA72-4 in gastric cancer cell line BGC-823 was investigated by cell experiment.The co-treatment of colchicine and serum in vitro was used to determine whether colchicine directly interfered with the detection of serum CA72-4.After the treatment of gastric cancer cell BGC-823 with different concentrations of colchicine for 24 hours,there was no statistically significant difference in the concentrations of CA72-4 in the cell supernatant of each group.While colchicine and patient's serum were co-treated in vitro for 1,2 and 3 hours,there was no statistically significant difference in the concentration of serum CA72-4 in each group.CA72-4 is one of the tumor markers indicating gastric cancer,but the mechanism of CA72-4 production in gastric cancer cells is not completely clear,and the mechanism of the increase of CA72-4 caused by colchicine is not fully clarified.Clinicians and clinical pathologists should consider the possible changes in serum CA72-4 concentration caused by drug factors.

关 键 词：秋水仙碱 痛风 糖类抗原72-4 

分 类 号：R735.2[医药卫生—肿瘤]