β淀粉样蛋白PET成像阳性人群的脑葡萄糖代谢研究进展  

Advances in Brain Glucose Metabolism Research in Individuals with Positive Amyloid-βProtein PET Imaging

作　　者：申佳妮 张肖南 吕亮亮 陈金雨 赵娅蓉 李阳 SHEN Jiani;ZHANG Xiaonan;LV Liangliang;CHEN Jinyu;ZHAO Yarong;LI Yang(The First Clinical Medical School of Shanxi Medical University,Tainyuan 030000,China)

机构地区：[1]山西医科大学第一临床医学院,太原030000

出　　处：《神经损伤与功能重建》2024年第6期362-365,共4页Neural Injury and Functional Reconstruction

基　　金：山西省医学重点攻关专项(认知障碍疾病患者多模态智能评估与干预系统研制及示范应用,No.2020XM22);中央引导地方科技发展专项资金项目(慢病患者多模态疾病感知及健康医疗大数据平台建设,No.YDZX20191400002563);山西省基础研究计划(基于功能及代谢影像学技术探讨PD-MCI患者双任务下异常步态的神经机制研究,No.202203021221255)。

摘　　要：阿尔茨海默病(AD)是常见的神经退行性疾病,也是全球范围痴呆的主要原因,目前尚无有效治疗方法。AD的早期发现与诊断,对改善预后具有重要的临床意义。研究表明,淀粉样蛋白PET和^(18)F-氟脱氧葡萄糖(^(18)F-FDG)PET成像有助于AD的早期诊断。本文对PET成像β淀粉样蛋白阳性的不同人群的脑葡萄糖代谢及二者间关系的研究进展做一综述。Alzheimer’s disease(AD)is a common neurodegenerative disorder and the leading cause of dementia worldwide,for which there is currently no effective treatment.The early detection and diagnosis of AD are clinically significant for improving prognosis.Studies have shown that amyloid PET and^(18)F-fluorodeoxyglucose(^(18)F-FDG)PET imaging are useful for the early diagnosis of AD.This article provides a review of the research progress on brain glucose metabolism in different populations with positive amyloidβ(Aβ)PET imaging and the relationship between the two.

关 键 词：阿尔茨海默病 β-淀粉样蛋白 ^(18)F-氟脱氧葡萄糖 正电子发射断层显像 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R742R816