自闭症谱系障碍的社会功能障碍:触觉与催产素  

Social Dysfunction in Autism Spectrum Disorder:Tactility and Oxytocin

作　　者：黄钰杰 赵荣 克丽比努尔·艾尔肯 李晶晶 王俊琪 潘海萍 高军 Huang Yujie;Zhao Rong;Ke Libinuer·aierken;Li Jingjing;Wang Junqi;Pan Haiping;Gao Jun

机构地区：[1]西南大学心理学部认知与人格教育部重点实验室,重庆400715

出　　处：《复印报刊资料（心理学）》2023年第9期96-110,共15页

基　　金：国家自然科学基金(32071059);重庆市自然科学基金(cstc2020jcyj-msxmX0209);中央高校基本科研业务费(SWU2109223);重庆市社科规划项目(2020PY64)。

摘　　要：自闭症谱系障碍(autism disorder,ASD)的核心症状之一是持续性的社会功能障碍。近年来大量的研究表明触觉输入可以通过调控催产素系统影响社会功能。同时,近年来提出的催产素的社会显著性理论认为,催产素可以通过增强对应脑区的激活程度从而提高社会信息的显著性。在此理论框架下,当社会互动发生时,触觉输入会增强催产素的合成与分泌,同时催产素也会提高触觉信息的显著性,从而进一步促进社会互动的进行。基于催产素的社会显著性理论,ASD患者的触觉敏感性异常以及催产素系统异常可能破坏触觉与催产素系统之间的相互调控机制,这可能是其社会功能缺陷的原因之一。探究触觉、催产素系统和社会功能三者的关系有助于我们了解社会功能障碍的发病机制,为未来的预防和干预手段提供新的思路。One of the core symptoms of autism spectrum disorder(ASD)is persistent social dysfunction.In recent years,many studies have indicated that tactile input can affect social function through regulating the oxytocin system.The affective touch conducted by C-fiber promotes the synthesis and release of oxytocin and enhances social motivation and social preference.According to the social salience hypothesis of oxytocin,oxytocin increases the salience of social information through enhancing activation of corresponding brain regions.Under this theoretical framework,when social interaction happens,tactile input can enhance the synthesis and release of oxytocin,and oxytocin can also increase the salience of tactile information,which further promotes the occurrence of social interaction.Previous studies have shown that people with ASD have deficits in the oxytocin system.The main manifestations are lower peripheral oxytocin concentration than normal developing individuals and the change of Single Nucleotide Polymorphism(SNP)of oxytocin receptor.People with ASD also show abnormal tactile sensitivity,including hypersensitivity and hyposensitivity.At the peripheral level,they manifest abnormal tactile threshold.At the central level,they manifest abnormal activation in the brains affective touch processing regions(such as insula).Based on the social salience hypothesis of oxytocin,this article summarizes the possible regulations between touch and oxytocin on social function.We point out that the deficits in the oxytocin system can decrease the salience of touch information in people with ASD,reducing the attention resources in social interaction and affecting the emotional feelings for touch.Abnormal tactile sensitivity results in social avoidance,which decreases the synthesis and release of oxytocin in social contact,decreasing the social motivation and social preference,ultimately resulting in social dysfunction.Exploring the interaction between touch,oxytocin system and social function can help us understand the pathogenesis

关 键 词：自闭症谱系障碍 社会性触摸 催产素 社会功能缺陷 感觉异常 

分 类 号：R749.94[医药卫生—神经病学与精神病学]