NT-proBNP、D-D、CRP检测在中老年急性脑梗死患者中的临床诊断价值分析  

Analysis of clinical value of NT-proBNP,D-D,CRP detection in middle-aged and elderly patients with acute cerebral infarction

作　　者：张伟[1] ZHANG Wei(Department of Clinical Laboratory,the First Hospital of Fangshan District,Beijing 102400,China)

机构地区：[1]北京市房山区第一医院检验科,102400

出　　处：《中国实用医药》2024年第10期81-84,共4页China Practical Medicine

摘　　要：目的 分析氨基末端脑钠肽前体(NT-proBNP)、D-二聚体(D-D)、C反应蛋白(CRP)检测对中老年急性脑梗死(ACI)患者的诊断价值。方法 选取中老年急性脑梗死患者52例为观察组[根据病灶直径不同分为大面积梗死组(>5 cm)10例、中面积梗死组(≤5 cm,>3 cm)16例、小面积梗死组(≤3 cm,>1.5 cm)26例],另选取健康体检者50例为对照组。观察组及对照组均进行D-D、CRP、NT-proBNP水平检测。比较观察组及对照组的CRP、D-D、NT-proBNP水平,观察组不同脑梗死面积患者的CRP、D-D、NT-proBNP水平。结果观察组CRP、D-D、NT-proBNP水平均高于对照组,差异具有统计学意义(P<0.05)。观察组中,大面积梗死组的NT-proBNP、D-D、CRP水平分别为(3351.70±940.97)pg/ml、(898.43±323.19)ng/ml、(41.79±11.08)mg/L,中面积梗死组的NT-proBNP、D-D、CRP水平分别为(1338.06±345.23)pg/ml、(573.88±312.67)ng/ml、(32.05±11.77)mg/L,小面积梗死组的NT-proBNP、D-D、CRP水平分别为(447.00±195.72)pg/ml、(334.15±229.81)ng/ml、(18.03±10.14)mg/L。大面积梗死组患者的NT-proBNP、D-D、CRP水平均高于中面积梗死组及小面积梗死组,中面积梗死组患者的NT-proBNP、D-D、CRP水平均高于小面积梗死组,差异具有统计学意义(P<0.05)。结论 D-D、CRP、NT-proBNP在诊断中老年急性脑梗死患者中存在较高的应用价值。Objective To analyze the diagnostic value of N-terminal pro-B-type natriuretic peptide(NT-proBNP),D-dimer(D-D)and C-reactive protein(CRP)in middle-aged and elderly patients with acute cerebral infarction(ACI).Methods 52 middle-aged and elderly patients with acute cerebral infarction were selected as the observation group[according to diameters of the infarct area,the observation group was divided into large-area infarction group(>5 cm,10 cases),small-area infarction group(≤5 cm and>3 cm,16 cases)and medium-area infarction group(≤3 cm and>1.5 cm,16 cases)],and another 50 healthy subjects were selected as the control group.D-D,CRP and NT-proBNP levels were detected in the observation group and the control group.The levels of CRP,D-D and NT-proBNP in the observation group and the control group were compared,and the levels of CRP,D-D and NT-proBNP in patients with different infarct area in the observation group were compared.Results The levels of CRP,D-D and NT-proBNP in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).In the observation group,the levels of NT-proBNP,D-D and CRP in the large-area infarction group were(3351.70±940.97)pg/ml,(898.43±323.19)ng/ml and(41.79±11.08)mg/L,respectively;the levels of NT-proBNP,D-D and CRP in the medium-area infarction group were(1338.06±345.23)pg/ml,(573.88±312.67)ng/ml and(32.05±11.77)mg/L,respectively;the levels of NT-proBNP,D-D and CRP in small-area infarction group were(447.00±195.72)pg/ml,(334.15±229.81)ng/ml and(18.03±10.14)mg/L,respectively.The levels of NT-proBNP,D-D and CRP in large-area infarction group were higher than those in medium-area infarction group and small-area infarction group;the levels of NT-proBNP,D-D and CRP in medium-area infarction group were higher than those in small-area infarction group;the difference was statistically significant(P<0.05).Conclusion D-D,CRP and NT-proBNP have high application value in the auxiliary diagnosis of acute cerebral infarction in th

关 键 词：D-二聚体 C反应蛋白 氨基末端脑钠肽前体 急性脑梗死 诊断价值 

分 类 号：R743.33[医药卫生—神经病学与精神病学]