血浆D-二聚体检测在食管癌诊断中的应用价值探讨  

Application value of detection of plasma D-dimer in the diagnosis of esophageal cancer

作　　者：陈豪[1] 许彬东[1] 陈鹏飞 刘信禹[1] CHEN Hao;XU Bin-dong;CHEN Peng-fei(Department of Thoracic and Cardiovascular Surgery,Affiliated Hospital of Putian University,Putian 351100,China)

机构地区：[1]莆田学院附属医院胸心外科,351100

出　　处：《中国实用医药》2024年第10期88-91,共4页China Practical Medicine

基　　金：福建省莆田市科技计划项目(项目编号:2018S3F011);莆田学院校级科研项目(项目编号:2022074)。

摘　　要：目的 探讨血浆D-二聚体检测在食管癌诊断中的应用价值。方法 选取60例接受手术治疗的食管癌患者作为食管癌组,术前及术后第1、14天检测血浆D-二聚体水平;另选取60例健康体检者作为对照组,体检时检测血浆D-二聚体水平。比较食管癌组术前与对照组D-二聚体水平及D-二聚体阳性率;比较食管癌组患者术前与术后D-二聚体水平;比较食管癌组不同临床特征患者术前D-二聚体水平及D-二聚体阳性率。结果 食管癌组术前D-二聚体水平为(0.65±0.25)mg/L,显著高于对照组的(0.32±0.16)mg/L(P<0.05);食管癌组术前D-二聚体阳性率35.00%(21/60)显著高于对照组的15.00%(9/60)(P<0.05)。食管癌组术后第1天D-二聚体水平为(1.21±0.49)mg/L,显著高于术前的(0.65±0.25)mg/L(P<0.05);食管癌组术后第14天D-二聚体水平为(0.35±0.15)mg/L,显著低于术前的(0.65±0.25)mg/L(P<0.05)。食管癌组不同性别(男性、女性)、年龄(<70岁、≥70岁)、肿瘤部位(胸上段、胸中段、胸下段及食管胃交界部)患者术前D-二聚体水平比较无差异(P>0.05);食管癌组不同分化程度及术后病理分期患者术前D-二聚体水平比较差异有统计学意义(P<0.05)。食管癌组不同性别(男性、女性)、年龄(<70岁、≥70岁)、肿瘤部位(胸上段、胸中段、胸下段及食管胃交界部)患者术前D-二聚体阳性率比较无差异(P>0.05);食管癌组不同分化程度及术后病理分期患者术前D-二聚体阳性率比较差异有统计学意义(P<0.05)。结论 血浆D-二聚体检测对食管癌的诊断具有一定的应用价值。Objective To explore the application value of detection of plasma D-dimer in the diagnosis of esophageal cancer.Methods A total of 60 esophageal cancer patients who underwent surgical treatment were selected as the esophageal cancer group.The plasma D-dimer level was detected before operation,on the 1st day after operation,and on the 14th day after operation.Another 60 healthy subjects were selected as the control group,and plasma D-dimer levels were detected during physical examination.Comparison was made on D-dimer level and D-dimer positivity rate between the esophageal cancer group before treatment and the control group,D-dimer levels preoperatively and postoperatively in the esophageal cancer group,as well as D-dimer levels and D-dimer positivity rate of patients with different clinical features in the esophageal cancer group.Results The preoperative D-dimer level in the esophageal cancer group was(0.65±0.25)mg/L,which was significantly higher than(0.32±0.16)mg/L in the control group(P<0.05);the preoperative D-dimer positivity rate in the esophageal cancer group was 35.00%(21/60),which was significantly higher than 15.00%(9/60)in the control group(P<0.05).The D-dimer level in the esophageal cancer group was(1.21±0.49)mg/L on the 1st day after operation,which was significantly higher than(0.65±0.25)mg/L before operation(P<0.05).The D-dimer level was(0.35±0.15)mg/L in the esophageal cancer group on the 14th day after operation,which was significantly lower than(0.65±0.25)mg/L before operation(P<0.05).In the esophageal cancer group,there were no differences in preoperative D-dimer level among patients with different sex(male and female),age(<70 years old,≥70 years old)and tumor site(upper thoracic segment,middle thoracic segment,lower thoracic segment and esophagogastric junction)(P>0.05).The difference in preoperative D-dimer levels of patients with different degree of differentiation and postoperative pathological stages in the esophageal cancer group was statistically significant(P<0.05).In the esoph

关 键 词：D-二聚体 食管癌 生物标志物 

分 类 号：R735.1[医药卫生—肿瘤]