Role of peripheral amyloid-β aggregates in Alzheimer’s disease: mechanistic, diagnostic, and therapeutic implications  

作　　者：Nazaret Gamez Rodrigo Morales 

机构地区：[1]Department of Neurology,The University of Texas Health Science Center at Houston,Houston,TX,USA [2]Centro Integrativo de Biologia y Quimica Aplicada(CIBQA),Universidad Bernardo O’Higgins,Santiago,Chile

出　　处：《Neural Regeneration Research》2025年第4期1087-1089,共3页中国神经再生研究（英文版）

基　　金：supported by grants from NIH(RF1AG072491 and R01AI132695)to RM.

摘　　要：Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer’s disease(AD)patients.Moreover,Aβdeposits have been identified in peripheral tissues.However,the relevance of peripheral Aβ(misfolded or not)in pathological situations,and the temporal appearance of these pathological fluctuations,are not well understood.The presence of misfolded Aβin peripheral compartments raises concerns on potential inter-individual transmissions considering the well-reported prion-like properties of this disease-associated protein.The latter is supported by multiple reports demonstrating that Aβmisfolding can be transmitted between humans and experimental animals through multiple routes of exposure.In this mini-review,we discuss the potential implications of peripheral,disease-associated Aβin disease mechanisms,as well as in diagnostic and therapeutic approaches.

关 键 词：therapeutic AMYLOID latter 

分 类 号：R749.16[医药卫生—神经病学与精神病学]