乳腺浸润性导管癌超声及超声造影征象与B7-H4表达的相关性  

Relationship between ultrasonography and contrast-enhanced ultrasonography and B7-H4 in breast invasive ductal carcinom

作　　者：张竞月 候雪琴[1] 晏睿谦 刘怡彬 李智铭 高军喜[1] ZHANG Jingyue;HOU Xueqin;YAN Ruiqian;LIU Yibin;LI Zhimin;GAO Junxi(Department of Ultrasound Diagnosis Abdomen,The First Affiliated Hospital,Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学第一附属医院腹部超声诊断科,新疆乌鲁木齐830011

出　　处：《分子影像学杂志》2024年第5期496-501,共6页Journal of Molecular Imaging

摘　　要：目的分析浸润性导管癌(IDC)超声及超声造影特征与B7同源体4(B7-H4)表达的相关性。方法回顾性分析2015年1月~2021年1月在新疆医科大学第一附属医院乳腺外科收治的136例乳腺病变女性患者,手术切除后标本经病理证实为IDC,将病理标本切片并采用免疫组化检测乳腺癌细胞的细胞膜和胞浆中B7-H4表达情况,所有患者术前均行乳腺二维超声检查及超声造影检查并记录病灶超声及超声造影特征,分析IDC超声及超声造影特征与B7-H4表达水平的相关性。结果136例患者免疫组化检测B7-H4在乳腺癌细胞的细胞膜和胞浆中均有表达。因抗原修复时温度过高或其他原因导致组织脱片2张,剩余134张切片中,阴性表达6张,阳性表达128张,其中高表达85张,低表达43张。不同的B7-H4表达分组中,B7-H4出现高表达时,IDC二维超声易出现纵横比>1、形态不规则、周围组织回声中断,后方回声衰减,淋巴结转移等特征(P<0.05);IDC超声造影易出现增强后病灶内部充盈缺损及增强后病灶周边汇聚征的特征(P<0.05)。二维IDC中肿块形态、纵横比、后方声衰减及周围组织回声等二维超声特征与B7-H4的高表达呈正相关(r=0.188、0.240、0.185、0.344,P<0.05)。结论IDC超声及超声造影表现与B7-H4的表达具有一定相关性,IDC超声及超声造影特征可以预测其分子标志物B7-H4的表达,进而可能为乳腺癌B7-H4靶向治疗效果评估提供可靠的影像学参考依据。Objective To analyze the relationship and correlation between ultrasonography and contrast-enhanced ultrasound features and the expression of B7-H4 in invasive ductal carcinoma(IDC).Methods A total of 136 female patients admitted to the Department of Breast Surgery,First Affiliated Hospital of Xinjiang Medical University from January 2015 to January 2021 were retrospectively analyzed.Following surgical resection,specimens were histopathologically confirmed as IDC.Immunohistochemistry was utilized to detect the expression of B7-H4 in the cell membrane and cytoplasm of breast cancer cells from the pathological specimens.Prior to surgery,all patients underwent two-dimensional ultrasound and contrast enhanced ultrasound of the breast.Ultrasound and contrast-enhanced ultrasound characteristics of the lesions were documented,and their correlation with the expression level of B7-H4 in IDC was subsequently analyzed.Results The expression of B7-H4 in the cell membrane and cytoplasm of breast cancer cells was detected by immunohistochemistry in 136 patients.Due to the high temperature during antigen repair or other reasons,2 pieces of tissue were removed.Among the remaining 134 sections,6 were negative expression and 128 were positive expression,including 85 high expression and 43 low expression.In different B7-H4 expression groups,when B7-H4 was highly expressed,the two-dimensional ultrasound of IDC mass was prone to characteristics such as aspect ratio>1,irregular shape,interruption of surrounding tissue echo,posterior echo attenuation,lymph node metastasis(P<0.05);The characteristics of IDC contrast-enhanced ultrasound were prone to the characteristics of internal filling defect and peripheral convergence sign after enhancement(P<0.05).The high expression of B7-H4 was positively correlated with the two-dimensional ultrasound features such as tumor morphology,aspect ratio,posterior acoustic attenuation and surrounding tissue echo in two-dimensional IDC ultrasound(r=0.188,0.240,0.185,0.344,P<0.05).Conclusion IDC ultrasoun

关 键 词：乳腺浸润性导管癌 B7-H4 超声检查 超声造影 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]