调节性细胞死亡在扩张型心肌病中的研究进展  

Research progress on the relationship between regulatory cell death and dilated cardiomyopathy

作　　者：邱月清 王振涛[1,2] 陈振翼[1,2] 常红波[1] 禹笑阳 薛祎琨 QIU Yueqing;WANG Zhentao;CHEN Zhenyi;CHANG Hongbo;YU Xiaoyang;XUE Yikun(the Second Clinical School of Henan University of Chinese Medicine,Zhengzhou 450053,China;Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450053)

机构地区：[1]河南中医药大学第二临床医学院,郑州450053 [2]河南省中医院,郑州450053

出　　处：《中国比较医学杂志》2024年第5期113-125,共13页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金面上项目(81573920);2021年河南省卫生健康委国家中医临床研究基地科研项目(2021JDZX2101);河南省中医学“双一流”创建科学研究专项(HSRP-DFCTCM-2023-1-20);2023年度河南省重点研发与推广专项(科技攻关)(232102310432)。

摘　　要：扩张型心肌病(dilated cardiomyopathy,DCM)起病隐匿,以左心扩大甚至全心扩大为主要影像学表现,是心力衰竭与心律失常的常见原发疾病之一。随着近年来研究的不断深入,调节性细胞死亡(regulatory cell death,RCD)的内在分子机制逐渐清晰,研究者们发现RCD方式在DCM的发生发展过程中扮演了十分重要的角色。目前已知DCM中所涉及的RCD方式主要包括凋亡、坏死性凋亡、焦亡、铁死亡、自噬、铜死亡等,并且它们之间具有一定的相关性,可相互作用和调控。本文就上述6种RCD方式参与DCM的机制研究现况进行概述,以期为未来基础研究及临床应用提供参考。Dilated cardiomyopathy(DCM)has a concealed onset with left or even whole heart enlargement as the main imaging manifestation.It is a common primary disease of heart failure and arrhythmia.With the continuous deepening of research in recent years,the intrinsic molecular mechanism of regulatory cell death(RCD)has gradually become clear.Researchers have found that the RCD mode plays a very important role in the occurrence and development of DCM.At present,the RCD modes involved in DCM mainly include apoptosis,necrotic apoptosis,pyroptosis,iron death,autophagy,and cuproptosis,and a certain correlation exists among them,which interact and regulate each other.This article provides an overview of the current research status on the mechanisms of the six RCD modes involved in DCM to provide a reference for future basic research and clinical applications.

关 键 词：扩张型心肌病 调节性细胞死亡 凋亡 坏死性凋亡 焦亡 自噬 铁死亡 铜死亡 

分 类 号：R-33[医药卫生]