SHP2在消化系统肿瘤中的研究进展  

Research progress of SHP2 in digestive system tumors

作　　者：王鹏[1] 樊建春 贾举名 刁庆飞 薛军[2,3] 武雪亮[2,3] WANG Peng;FAN Jianchun;JIA Juming;DIAO Qingfei;XUE Jun;WU Xueliang(Hebei North University,Zhangjiakou 075000,China;Department of General Surgery,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000;Cancer Research Institute,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000)

机构地区：[1]河北北方学院,河北张家口075000 [2]河北北方学院附属第一医院普通外科,河北张家口075000 [3]河北北方学院附属第一医院肿瘤研究所,河北张家口075000

出　　处：《中国比较医学杂志》2024年第5期159-168,共10页Chinese Journal of Comparative Medicine

基　　金：2022年河北省省自然科学精准医学联合基金项目(H2022405033)。

摘　　要：目前恶性肿瘤已经成为威胁人类身体健康的主要疾病之一,致残率、致死率在逐年上升。Src同源性2的蛋白酪氨酸磷酸酶2(src homology 2 domain-containing protein tyrosine phosphatase 2,SHP2)是蛋白酪氨酸磷酸酶(proteintyrosine phosphatase,PTP)家族中重要的一员,是一种功能广泛的酪氨酸磷酸酶,其在多种实体肿瘤中的表达量升高,在侵袭、转移、增殖、凋亡、耐药性等方面发挥着重要调控作用。已有大量研究表明,SHP2在许多实体瘤的发生和发展中起着非常重要的作用,但现在尚无系统的报道SHP2在消化系统肿瘤中的作用。基于此该文综述了SHP2在7种消化系统中不同肿瘤的生物学功能及临床意义,探讨其在不同癌症发展阶段的作用与机制,并总结与展望SHP2抑制剂的发展,进一步寻找有效的早期诊断和基因治疗的潜在靶点,这对癌症患者生存率的提高具有十分重要的意义。Malignant tumors are a major disease threatening human health with disability and mortality rates increasing yearly.Protein tyrosine phosphatase 2(SHP2)of Src homology 2,an important member of the protein tyrosine phosphatase family,has a wide range of functions,and its expression is elevated in a wide range of solid tumors.SHP2 plays an important regulatory role in invasion,metastasis,proliferation,apoptosis,and drug resistance.A large number of studies have shown that SHP2 plays a very important role in the genesis and development of many solid tumors,but no systematic studies have reported on the role of SHP2 in digestive system tumors.Here,we reviewed the biological functions and clinical significance of SHP2 in seven tumor types of the digestive system,explored its roles and mechanisms in cancer development stages,and summarized the development of SHP2 inhibitors to further search for potential targets for effective early diagnosis and gene therapy,which is of great significance to improvement the cancer patient survival rate.

关 键 词：SHP2 消化道肿瘤 作用机制 临床研究 

分 类 号：R-33[医药卫生]