顶花板凳果的化学成分研究  

Chemical compositions of Pachysandra terminalis

作　　者：刘辰旺 吴莹 李昕卓 张玉莹 龚传明 张嘉怡 李玉泽[1,2] 宋小妹 张东东[1,2] LIU Chen-wang;WU Ying;LI Xin-zhuo;ZHANG Yu-ying;GONG Chuan-ming;ZHANG Jia-yi;LI Yu-ze;SONG Xiao-mei;ZHANG Dong-dong(School of Pharmacy,Shaanxi University of Chinese Medicine,Xianyang Shaanxi 712046;Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao”,Xianyang Shaanxi 712046)

机构地区：[1]陕西中医药大学药学院,陕西咸阳712046 [2]陕西省太白七药研究与应用重点研究室,陕西咸阳712046

出　　处：《中南药学》2024年第5期1131-1134,共4页Central South Pharmacy

基　　金：国家自然科学基金项目(No.82104368);陕西中医药大学创新团队项目(No.2023-CXTD-05)。

摘　　要：目的 研究顶花板凳果(Pachysandra terminalis Sieb.et Zucc.)的化学成分。方法 采用硅胶柱色谱、凝胶柱色谱以及半制备液相色谱等方法进行分离纯化,并结合其理化性质及NMR、IR、MS等波谱学技术进行结构解析。结果 从顶花板凳果80%乙醇提取物中分离得到10个化合物,分别为(+)-syringaresinol(1)、苯甲酸(2)、对羟基苯甲醛(3)、对羟基苯乙酮(4)、香草酸(5)、丁香醛(6)、4-羟基-3,5-二甲氧基苯乙酮(7)、3,4,5-三甲氧基苯甲酸(8)、3-羟基-1-(4-羟基-3,5-二甲氧基苯)-1-丙酮(9)、schumannione(10)。结论 化合物1~4、7~10为首次从板凳果属植物中分离得到。Objective To determine the chemical constituents of Pachysandra terminalis Sieb.et Zucc..Methods The separation and purification were conducted by silica gel column chromatography,gel column chromatography and semi-preparative liquid chromatography.The structural was analyzed by combining its physicochemical properties and spectroscopic techniques such as NMR,IR and MS.Results Ten compounds were isolated from 80%ethanol extract of Pachysandra terminalis and identified as(+)-syringaresinol(1),benzoic acid(2),4-hydroxy benzaldehyde(3),4-hydroxyacetophenone(4),vanillic acid(5),syringaldehyde(6),4-hydroxy-3,5-dimethoxyacetophenone(7),3,4,5-trimethoxylbenzoic acid(8),3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone(9),and schumannione(10).Conclusion Compounds 1~4,and 7~10 have been isolated for the first time from Pachysandra.

关 键 词：顶花板凳果 提取分离 化学成分 结构鉴定 木脂素类 酚类 

分 类 号：R284.2[医药卫生—中药学]