导管溶栓前小球囊预扩张治疗急性髂股静脉血栓患者的临床及安全性  

Effect and Safety of Small Balloon Pre-Dilation before Catheter Thrombolysis in the Treatment of Acute Iliofemoral Vein Thrombosis Patients

作　　者：邱书森 QIU Shusen(Ningling County People's Hospital,Shangqiu Henan 476799)

机构地区：[1]宁陵县人民医院,河南商丘476799

出　　处：《医学临床研究》2024年第5期645-648,共4页Journal of Clinical Research

摘　　要：【目的】探讨导管溶栓前小球囊预扩张治疗急性髂股静脉血栓患者的效果及安全性。【方法】选取2018年1月至2021年12月本院收治的116例急性髂股静脉血栓患者作为研究对象,根据干预方法不同分为小球囊扩张联合导管溶栓治疗(观察组,n=53)及直接导管溶栓治疗(对照组,n=63)。比较两组患者治疗前及治疗一周时健侧与患侧的周径差、静脉通畅评分、静脉通畅率、凝血酶原时间(PT)、纤维蛋白原(FIB)水平、活化部分酶凝血酶时间(APTT)、凝血酶时间(TT)、白细胞计数(WBC)、D-二聚体(D-D),并记录两组患者出血发生率、溶栓时间、尿激酶用量及住院时间。【结果】治疗后,两组患者大腿周径差、小腿周径差均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者深静脉通畅评分均低于治疗前,且观察组低于对照组(P<0.05);观察组深静脉通畅率高于对照组,出血发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者TT、APTT、PT均长于治疗前,且观察组长于对照组(P<0.05);两组FIB水平显著低于治疗前,且观察组低于对照组(P<0.05)。治疗后,观察组WBC、D-D水平均低于治疗前,且观察组低于对照组(P<0.05)。观察组溶栓时间、尿激酶用量及住院时间均少于对照组,差异有统计学意义(P<0.05)。【结论】导管溶栓前使用小球囊预扩张治疗急性髂股静脉血栓可提高治疗疗效,安全性高,且具有预后静脉通畅率高、使用溶栓药物剂量少、溶栓时间短、出血发生率低等优点。【Objective】To explore the efficacy and safety of pre dilation of small balloons before catheter thrombolysis in the treatment of acute iliofemoral vein thrombosis patients.【Methods】A total of 116 patients with acute iliofemoral vein thrombosis admitted to our hospital from January 2018 to December 2021 were selected as the study subjects.According to the intervention method,they were divided into small balloon dilation combined with catheter thrombolysis treatment(observation group,n=53)and direct catheter thrombolysis treatment(control group,n=63).Comparison was made between two groups of patients before treatment and one week after treatment,including the circumference difference between the healthy and affected sides,venous patency score,venous patency rate,prothrombin time(PT),fibrinogen(FIB)levels,activated partial enzyme thrombin time(APTT),thrombin time(TT),and white blood cell count(WBC)D-dimer(D-D)was used to record the incidence of bleeding,thrombolysis time,dosage of urokinase,and length of hospital stay in two groups of patients.【Results】After treatment,the difference in thigh circumference and calf circumference between the two groups of patients was lower than before treatment,and the observation group was lower than the control group,with statistical significance(P<0.05).After treatment,the deep vein patency scores of both groups of patients were lower than before treatment,and the observation group was lower than the control group(P<0.05);The deep vein patency rate and bleeding incidence rate in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,two groups of patients TT The levels of APTT and PT were higher than before treatment,and the observation group was higher than the control group.The FIB levels in both groups were significantly lower than before treatment,and the observation group was lower than the control group(P<0.05).After treatment,the WBC and D-D levels in the observation group were lo

关 键 词：静脉血栓形成/治疗 急性病 血栓溶解疗法/方法 治疗结果 

分 类 号：R364.15[医药卫生—病理学]