帕金森病患者血清cys C、UA、Hcy、NSE水平与病情严重程度的相关性分析  

Correlation of the Severity of Parkinson's Disease with Serum Levels of cys C,UA,Hcy,and NSE

作　　者：郭利娜 赵晓玲 王艳蕊[2] GUO Lina;ZHAO Xiaoling;WANG Yanrui(Department of General Medicine,Anyang People's Hospital,Anyang Henan 455000)

机构地区：[1]安阳市人民医院全科医学科,河南安阳455000 [2]濮阳市安阳地区医院全科医学科,河南安阳455000

出　　处：《医学临床研究》2024年第5期685-687,692,共4页Journal of Clinical Research

摘　　要：【目的】探讨帕金森病患者血清胱抑素(cys C)、尿酸(UA)、同型半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)水平与病情严重程度的相关性。【方法】回顾性分析120例帕金森病患者的临床资料,统计患者的一般资料及血脂指标、凝血指标、cys C、UA、Hcy、NSE水平等数据,采用多因素Logistic回归分析法分析影响帕金森病患者病情严重程度的独立危险因素,采用Spearman检验分析相关指标与患者病情严重程度的相关性。【结果】120例患者中有43例(35.83%)患者为早期,纳为早期组;其余77例(64.17%)为中晚期,纳为中晚期组。两组病程、年龄、性别、血红蛋白、血小板、凝血指标、血压、血脂水平等比较,差异均无统计学意义(P>0.05)。中晚期组患者cys C、Hcy、NSE水平均高于早期组(P<0.05),UA水平低于早期组(P<0.05)。多因素Logistic回归分析显示,cys C、Hcy、NSE是影响帕金森病患者病情严重程度的独立危险因素(P<0.05),UA是影响患者病情严重程度的保护因素(P<0.05)。Spearman检验结果显示,帕金森病患者病情严重程度与cys C、Hcy、NSE水平呈正相关,与UA呈负相关(P<0.05)。【结论】cys C、Hcy、NSE是影响帕金森病患者病情严重程度的危险因素,UA是保护因素,其水平均与患者病情严重程度密切相关,需引起临床重视。【Objective】To explore the correlation of the severity of Parkinson's disease with the serum levels of cystatin C(cys C),uric acid(UA),homocysteine(Hcy),and neuron-specific enolase(NSE).【Methods】A retrospective analysis was conducted on the clinical data of 120 Parkinson's disease patients.Patient demographics,lipid profiles,coagulation markers,and levels of cys C,UA,Hcy,and NSE were statistically analyzed.Multivariate logistic regression was used to identify independent risk factors affecting the severity of the disease,while the Spearman test was utilized to analyze the correlation between these biomarkers and disease severity.【Results】Of the 120 patients,43(35.83%)were in the early stage of the disease,classified as the early group;the remaining 77(64.17%)were in the middle to late stages,classified as the middle-late group.Comparisons of disease duration,age,gender,hemoglobin,platelets,coagulation markers,blood pressure,and lipid levels between the groups showed no statistically significant differences(P>0.05).The levels of cys C,Hcy,and NSE were significantly higher in the middle-late stage group compared to the early stage group(P<0.05),while UA level in the middle-late stage group was lower than that in the early stage group(P<0.05).Multivariate logistic regression analysis indicated that cys C,Hcy,and NSE were independent risk factors for the severity of Parkinson's disease(P<0.05),whereas UA served as a protective factor(P<0.05).Spearman test results showed a positive correlation of disease severity with levels of cys C,Hcy,and NSE,while a negative correlation of the severity with UA(P<0.05).【Conclusion】cys C,Hcy,and NSE are risk factors that affect the severity of Parkinson's disease,while UA acts as a protective factor.The levels of these biomarkers are closely related to the severity of the condition,which should be paid good attention clinically.

关 键 词：帕金森病 抑素类/血液 尿酸/血液 半胱氨酸/血液 磷酸丙酮酸水合酶/血液 

分 类 号：R742.5[医药卫生—神经病学与精神病学]