CDH1单核苷酸多态性与上皮性卵巢癌患者临床预后的关联性  

Association between CDH1 single nucleotide polymorphism and clinical prognosis of epithelial ovarian cancer

作　　者：王娟[1] 刘蕾蕾 李琰[2] 康山 WANG Juan;LIU Leilei;LI Yan(Department of Obstetrics and Gynecology,Fourth Hospital of Hebei Medical University,Hebei,Shijiazhuang 050011,China;不详)

机构地区：[1]河北医科大学第四医院妇产科,石家庄市050011 [2]河北医科大学第四医院肿瘤研究所,石家庄市050011

出　　处：《河北医药》2024年第11期1611-1616,共6页Hebei Medical Journal

基　　金：河北省医学科学研究课题计划项目(编号:20191008)。

摘　　要：目的探讨E-cadherin基因(CDH1)启动子区3个遗传性多态位点-160C/A、-347G/GA和3’UTR+54C/T与上皮性卵巢癌(EOC)患者临床预后之间的关系。方法运用聚合酶链反应(PCR)方法对412例上皮性卵巢癌患者CDH1基因启动子区-160C/A、-347G/GA和3’UTR+54C/T遗传性多态位点的基因型频率分布情况进行分析。结果Logistic回归显示,患者的年龄、FIGO分期及残余癌灶的大小与EOC患者5年临床预后具有相关性(P<0.05);患者的年龄、FIGO分期与3年的临床预后具有相关性,而残余肿瘤的大小仅与患者3年复发相关。生存分析提示CDH1-347 G/GA多态性与EOC患者5年临床预后相关。与携带G/G基因型的EOC患者比较,携带GA/GA基因型的患者中位PFS和OS时间最短,携带G/GA的患者次之。调整预后因素后(年龄、FIGO分期及肿瘤残余大小),相对于携带G/G基因型的患者,携带GA/GA基因型的EOC患者有较高的疾病复发风险(H R=2.50;95%CI=1.51~4.13)和死亡风险(H R=2.50;95%CI=1.51~4.14)。结论CDH1-347 GA/GA位点的多态性与中国北方女性EOC患者预后显著相关。CDH1-347 GA/GA位点多态性有可能成为上皮性卵巢癌患者临床预后的生物学标志物。Objective To explore the association of the E-cadherin gene(CDH1)single nucleotide polymorphisms(SNPs)of 160C/A,-347G/GA and 3’UTR+54C/T with the clinical prognosis of epithelial ovarian canceRpatients(EOC).Methods The genotype distribution of-160C/A,-347G/GA and 3’UTR+54C/T genetic polymorphisms in the CDH1 gene promoteRregion in 412 EOC patients was detected by polymerase chain reaction(PCR).Results The logistic regression indicated that age,International Federation of Gynecology and Obstetrics(FIGO)staging,and tumoRresidual size were related to the 5-yeaRclinical outcomes of EOC patients(P<0.05).The age and FIGO staging were associated with 3-yeaRclinical prognosis,while the residual tumoRsize was only associated with 3-yeaRrecurrence.K-M survival analysis showed that CDH1-347 GA/GA polymorphism was correlated with 5-yeaRprognosis of EOC patients.EOC patients carrying GA/GA genotype had a significantly shorteRmedian progression-free survival(PFS)and overall survival(OS)compared with those carrying the G/G CDH1 genotype,followed by EOC patients carrying GA/GA genotype.Cox multivariate regression demonstrated that,afteRadjusting foRprognostic factors(age,FIGO staging,and tumoRresidual size),EOC patients carrying the GA/GA CDH1 genotype had higheRrisks of recurrence(HR=2.50;95%CI=1.51-4.13)and death(HR=2.50;95%CI=1.51-4.14)compared with those carrying the G/G genotype.Conclusion CDH1-347 GA/GA SNP is significantly associated with the clinical prognosis of EOC.CDH1-347 GA/GA SNP may be a biomarkeRfoRclinical prognosis of EOC.

关 键 词：CDH1 上皮性卵巢癌 多态性 临床预后 

分 类 号：R737.31[医药卫生—肿瘤]