恶性肿瘤并发口腔溃疡现代研究进展  

Modern research progress on malignant tumors combined with oral ulcers

作　　者：杜春海 赵灿 孙谦 DU Chunhai;ZHAO Can;SUN Qian(Second Department of Oncology,Hengshui Hospital of Traditional Chinese Medicine,Hebei,Hengshui 053000,China)

机构地区：[1]河北省衡水市中医医院肿瘤二科,053000

出　　处：《河北医药》2024年第11期1721-1725,共5页Hebei Medical Journal

基　　金：河北省中医药管理局科研计划项目(编号:2021360)。

摘　　要：口腔溃疡是抗肿瘤治疗过程中常见不良反应之一,主要表现为不同程度的口腔局部炎症、口腔疼痛、吞咽困难、口干、味觉障碍、继发感染等,且容易反复发作,给患者生活造成了极大的困扰。出现这种并发症,主要由于放射线或者抗肿瘤药物杀死肿瘤细胞的同时损伤了口腔黏膜上皮细胞,导致组织萎缩和溃疡;或者间接影响患者免疫系统,导致机体抵抗力下降,细菌在粘膜破损处入侵所致。虽然针对口腔溃疡已经制定和发布了多部防治及护理相关指南,但临床过程中尚未引起足够的重视,缺乏积极、有效的预防措施,以及尚无针对肿瘤相关性口腔溃疡的特效药物,严重者甚至无法耐受痛苦而影响抗肿瘤治疗的顺利进行。本文综述恶性肿瘤并发口腔溃疡研究进展,为临床诊疗及进一步研究提供参考。Oral ulcers are one of the common adverse events in anti-tumoRtherapy,presenting the main manifestations of oral local inflammation,oral pain,dysphagia,xerostomia,dysgeusia,secondary infection,etc.Oral ulcers are recurrent that pose discomfort to daily live.Radiation oRanti-tumoRagents kill tumoRcells and spontaneously impaiRoral mucosal epithelial cells,leading to oral tissue atrophy and ulcers.In addition,anti-tumoRtherapy indirectly influences the immunity.The decreased resistance of the host provides an opportunity of bacteria invasion into the mucosal damage area.Although many guidelines foRprevention and treatment of oral ulcers have been issued,clinical practice has not been highlighted.So far,the active and effective preventive measures are lacking,and there is no specific drugs foRthe treatment of tumor-associated oral ulcers.Severe oral ulcers with intolerable pain affect the smooth progress of anti-tumoRtherapy.This article reviewed the research progress of oral ulceRcombined by malignant tumors,in ordeRto provide references foRclinical diagnosis and treatment and furtheRresearch.

关 键 词：恶性肿瘤 口腔溃疡 现代研究 综述 

分 类 号：R730.5[医药卫生—肿瘤]