转化生长因子-β_(1)诱导多脏器纤维化机制的研究进展  

Research progress on the mechanism of multiple organ fibrosis induced by transforming growth factorβ_(1)

作　　者：李鹏宇 夏瑜(综述) 李飞(审校)[2] Li Pengyu;Xia Yu;Li Fei(The First Clinical Medical College,Kunming Medical University,Yunnan Province,Kunming 650500,China)

机构地区：[1]昆明医科大学第一临床医学院,昆明650500 [2]昆明医科大学

出　　处：《疑难病杂志》2024年第6期760-763,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：云南省科技厅科技计划项目(202101AY070001-040)。

摘　　要：脏器纤维化是多种慢性疾病的共同病理标志,转化生长因子-β_(1)(TGF-β_(1))可促进肌成纤维细胞增殖与活化,促进细胞外基质沉积并抑制其降解,并通过介导经典通路参与纤维化的发生。文章结合炎性反应和免疫应答、非编码RNA(ncRNA)以及信号通路之间串扰的相互作用,对TGF-β_(1)诱导各脏器纤维化的具体分子机制进行综述。Organ fibrosis is a common pathological marker of a variety of chronic diseases.In this paper,under the background of the study of transforming growth factor-β_(1)(TGF-β_(1))mediated classical pathway,the specific molecular mechanism of TGF-β_(1) induced fibrosis of various organs was summarized in combination with the interaction between inflammation and immune response,non-coding RNA(ncRNA)and signaling pathways.

关 键 词：脏器纤维化 转化生长因子-β_(1) 作用机制 

分 类 号：R364.3[医药卫生—病理学]