氧化应激在年龄相关性眼病中的作用机制研究进展  

Research progress of oxidative stress in age-related eye diseases

作　　者：陈雄 陈惠媚[1,2,3] 汤钰(综述) 姚小磊(审校) Chen Xiong;Chen Huimei;Tang Yu;Yao Xiaolei(Department of Ophthalmology,The First Hospital of Hunan University of Chinese Medicine,Hunan Province,Changsha 410007,China)

机构地区：[1]湖南中医药大学第一附属医院眼科,长沙410007 [2]湖南中医药大学,长沙410208 [3]中医药防治眼耳鼻咽喉疾病湖南省重点实验室/湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心,长沙410208

出　　处：《疑难病杂志》2024年第6期764-768,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金面上资助项目(82174443);湖南省教育厅资助项目(23A0290);湖南省研究生科研创新项目(2022CX136)。

摘　　要：氧化应激(OS)是指人体在内外环境的有害刺激下,氧化与抗氧化作用失衡,导致活性氧自由基和活性氮自由基堆积所产生的生理和病理反应。它是导致许多急慢性疾病和衰老的重要机制。眼球作为人体的视觉器官,长时间与外界环境接触,加上其代谢旺盛,其结构更易受到OS的损伤,引起眼部疾病的发生。因此,文章就氧化应激因素及其在年龄相关性眼病中的作用机制进行综述,并对目前主要的老年性眼病的OS机制分别进行阐述。Oxidative stress(OS)denotes the physiological and pathological response resulting from an imbalance between oxidation and antioxidation under the deleterious influence of internal and external stimuli.This imbalance leads to the accumulation of active oxygen free radicals and active nitrogen free radicals.OS serves as a crucial mechanism contributing to various acute and chronic diseases,as well as the aging process.As the visual organ of the human body,eyeball is consistently exposed to the external environment and undergoes robust metabolism,its structure is particularly susceptible to OS-induced damage,consequently giving rise to eye diseases.Therefore,this paper provides a comprehensive review of oxidative stress factors and their mechanisms in age-related eye diseases,elucidating the OS mechanisms prevalent in major senile eye diseases.

关 键 词：年龄相关性眼病 氧化应激 衰老 活性氧 作用机制 

分 类 号：R77[医药卫生—眼科]