Preparation, characterization and evaluation of kaempferol phospholipid complex: Improvement of its solubility and biological effect  

作　　者：Dezhi Gao Honghui Zhao Fengmao Zou Ming Yang Jing Wang Lina Fang Xu Zhao 

机构地区：[1]Faculty of Functional Food and Wine,Shenyang Pharmaceutical University,Shenyang 110016,China [2]School of Traditional Chinese Material Medica,Shenyang Pharmaceutical University,Shenyang 110016,China [3]College of Pharmacy,Shenyang Medical College,Shenyang 110034,China

出　　处：《Journal of Polyphenols》2024年第2期56-64,共9页多酚杂志（英文）

基　　金：funded by Young and Middle Aged Teachers’Career Development Support Project of Shenyang Pharmaceutical University(ZQN2019005).

摘　　要：Kaempferol(KA),as one of the flavonoids,has extensive pharmacological properties.However,the poor solubility of KA severely limits its clinical application.In our study,the kaempferol phospholipid complex(KA-PC)has been prepared by solvent evaporation for the enhancement of the bioavailability of KA.KA-PC was verified by scanning electron microscope characterization methods.Drug loading,solubility and long-term stability were measured.The characterization results showed that KA-PC was formed through the intermolecular interaction between KA and phospholipids.The solubility of KA-PC in water was 189 times higher than that of KA,and the solubility in n-octanol was also significantly improved.Besides,pharmacodynamic studies showed that KA-PC can significantly reduce the level of serum uric acid in mice without causing renal injury.This study expanded the clinical application of KA by preparing KA-PC.

关 键 词：KAEMPFEROL phospholipid complex SOLUBILITY uric acid-lowering effect 

分 类 号：R285[医药卫生—中药学]